Browsing Department of Medical Biochemistry by Title
Now showing items 233-252 of 282
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Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia
(Wiley Subscription Services, Inc., A Wiley Company, 2012)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children aged <48 months and manifests as severe malarial anemia [SMA; hemoglobin (Hb) < 6.0 g/dL]. Induction of high levels of ... -
Reference intervals for some biochemical parameters in the aged Kenyan population.
(East African Medical Journal,, 1994)Serum levels for sodium, potassium, calcium, inorganic phosphate, urea nitrogen and creatinine were determined in 1101 male and 181 female patients aged 50 years and above. The determinations were carried out on the SMA ... -
Reflections on the first pan‐african conference on biochemistry and molecular biology
(Headington Hill Hall, 1997-07-01)After a couple of years of consultations with leading biochemists/molecular biologists in Africa and from abroad (playing advisory roles), the First Pan-African Conference on Biochemistry and Molecular Biology was ... -
Reproductive toxicology: Edited by Raphael J Witorsch. pp 335. Raven Press, New York. 1995 ISBN 0‐7818‐0225‐9
(Headington Hill Hall, 1995-07-01)This volume incorporates material on stilbenes, bibenzyls, phenanthrene, their 9, 10- derivatives, and related plant products (similar in biosynthesis to fiavonoids), all derived from cinnamic acid and malonyl-CoA. The ... -
Research capacity. Enabling the genomic revolution in Africa.
(Science (New York, NY), 2014-06-01)Our understanding of genome biology, genomics, and disease, and even human history, has advanced tremendously with the completion of the Human Genome Project. Technological advances coupled with significant cost reductions ... -
A review of electroencephlagrams done at the Kenyatta National Hospital, Nairobi
(East African Medical Journal, 2008-06-11)Background: Electroencephalogram based studies done elsewhere suggest that epileptiform activity originates predominantly from the left cortical hemisphere. There is evidence that partial epilepsies (focal spike and wave ... -
Rheumatic fever and rheumatic heart disease: where are we now in South Africa?: ASAP programme
(The South African Heart Association, 2009)South Africa continues to face unacceptably high rates of rheumatic fever (RF) and rheumatic heart disease (RHD), despite readily available and inexpensive preventive measures. However, in the past several years, key players ... -
Risk of conjunctival contamination from blood splashes during surgery at the Kenyatta National Hospital, Nairobi
(East African medical journal, 2008-12-15)Objectives: To determine the utilisation rate of design specific eye protection by surgeons and to assess the risk of conjunctival contamination with blood splashes during surgery. Design: Cross sectional, observational ... -
The role of echocardiography in diagnosing carditis in the setting of acute rheumatic fever
(Cambridge University Press, 2009-08)Sir, Vijayalakshmi and her colleagues are to be commended for their paper.1 We disagree, however, with the use of a scoring system to make an echocardiographic diagnosis of carditis due to acute rheumatic fever. We ... -
The Role of Mobile Health in Supporting Cancer Prevention, Detection, Treatment and Palliative Care in Low and Middle Income Countries: A Scoping Review
(Scientific & Academic Publishing, 2017)Cancer is one of the non-communicable diseases with high morbidity and mortality rates, particularly in low-and-middle income countries. Increasing cancer burden is attributable to lifestyle risk factors, poor health ... -
Safety and Acceptability of Thermal Ablation for Treatment of Human Papillomavirus Among Women Living With HIV in Western Kenya
(American Society of Clinical Oncology, 2020-07)PURPOSE The WHO now recommends thermal ablation as an alternative to cryotherapy within “screen-and-treat” cervical cancer programs in low- and middle-income countries (LMICs). We conducted a safety and acceptability ... -
Safety and immunogenicity of RTS, S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial
(Elsevier, 2016)Background Malaria remains a major global public health concern, especially in sub-Saharan Africa. The RTS,S/AS01 malaria candidate vaccine was reviewed by the European Medicines Agency and received a positive scientific ... -
Safety and immunogenicity of the RTS, S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa
(Vaccine, 2020)We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African ... -
Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa
(Taylor & Francis, 2019)A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-Saharan Africa showed RTS,S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children (enrolled ... -
Same day colposcopic examination and loop electrosurgical excision procedure (LEEP) presents minimal overtreatment and averts delay in treatment of cervical intraepithelial …
(Scientific Research Publishing, 2013-05-08)Background: Screening for cancer of the cervix at Kenyatta National Hospital (KNH), follows the recommended three-step strategy; Papanicolaou (Pap) smear, colposcopy/biopsy and loop electrosurgical excision procedure ... -
Screening of Bioactive Secondary Metabolites from Sea Sponge (Clathria Indica) Against Bacteria Associated with Urinary Tract Infections
(Journal of the Open University of Tanzania, 2013)The marine sponge Clathria indica, collected from Thondi-Palk Strait region of Tamil Nadu, was studied for bacterial antagonistic activity. Sponge species were identified based on specula morphology. Ethyl Acetate extracts ... -
Sehistosoma Mansoni in the Baboon: Modulation of Pathology After Vaccination with Polyclonal Anti‐Idiotypic Antibodies
(Blackwell Publishing Ltd, 1995-12-01)Vaccination of five baboons with an anti-idiotypic vaccine to irradiated Schistosoma mansoni cercariae resulted in nearly 19% protection compared to 39% protection conferred to five baboons vaccinated with an irradiated ... -
Selective Blockade of Trypanosomatid Protein Synthesis by a Recombinant Antibody Anti-Trypanosoma cruzi P2β Protein
(Public Library of Science, 2012-05-03)The ribosomal P proteins are located on the stalk of the ribosomal large subunit and play a critical role during the elongation step of protein synthesis. The single chain recombinant antibody C5 (scFv C5) directed against ... -
Seroprevalence of hepatitis B surface antigen and it’s associated factors among hiv positive pregnant women in Jaramogi Oginga Odinga Teaching and Referral
(University of Nairobi, 2015)Introduction: Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) are among the leading causes of infectious disease deaths worldwide. The two viruses are highly endemic in sub-Saharan Africa. Pregnant women who ... -
Serum cystatin C for assessment of glomerular filtration rate in hypertensive disorders of pregnancy
(Taylor & Francis, 2004-01-01)Assessment of renal function is important in the evaluation of the pregnant hypertensive patient. The aim of this study was to evaluate the diagnostic utility of cystatin C as a marker of glomerular filtration rate in ...