• Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels 

  Okumu, Wilson; Okeyo, Winnie A; Munde, Elly O; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BioMed Central, 2013-12)

  In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
• (− 7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels 

  Okumu, Wilson; Okeyo, Winnie A; Munde, Elly O; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (Bio Med Central, 2013)

  In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
• Elly O. Munde, Winnie A. Okeyo, Samwel B. Anyona, Evans 

  Okumu, Wilson; Vulule, John; Ouma, Collins; Raballah, Stephen Konah; Ogonda, Lilian (2012)

  An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (Fc ...
• The lipid acyl-chain dynamics in giant liposomes and characterization of domain 4 of the Wilson disease protein 

  Okumu, Wilson (2010)

  Steady-state and nanosecond time-resolved fluorescence of the nitro-2, 1, 3- benzoxadiazol-4-yl (NBD) probe and line tension force were determined in phospholipids acyl-chain dynamics in giant liposomes made from a homologous ...
• Selective Blockade of Trypanosomatid Protein Synthesis by a Recombinant Antibody Anti-Trypanosoma cruzi P2β Protein 

  Ayub, Maximiliano J; Nyambega, Benson; Simonetti, Leandro; Duffy, Tomas; Longhi, Silvia A; Gómez, Karina A; Hoebeke, Johan; Levin, Mariano J; Smulski, Cristian R (Public Library of Science, 2012-05-03)

  The ribosomal P proteins are located on the stalk of the ribosomal large subunit and play a critical role during the elongation step of protein synthesis. The single chain recombinant antibody C5 (scFv C5) directed against ...
• Proteins Associated with SF3a60 in T. brucei 

  Nyambega, Benson; Helbig, Claudia; Masiga, Daniel K; Clayton, Christine; Levin, Mariano J (Public Library of Science, 2014-03-20)

  Trypanosoma brucei relies on Spliced leader trans splicing to generate functional messenger RNAs. Trans splicing joins the specialized SL exon from the SL RNA to pre-mRNAs and is mediated by the trans-spliceosome, which ...
• An investigation into factors predisposing workers to high levels of Pesticide exposure in Machakos District, Kenya 

  Momanyi, Violet N; Nyambega, Benson; Onyango, Mary A (2015-11)
• Depletion of trypanosome CTR9 leads to gene expression defects 

  Ouna, Benard A; Nyambega, Benson; Manful, Theresa; Helbig, Claudia; Males, Matilda; Fadda, Abeer; Clayton, Christine (Public Library of Science, 2012-04-20)

  The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA ...
• Functional characterization and protein–protein interactions of trypanosome splicing factors U2AF35, U2AF65 and SF1 

  Vazquez, Martin P; Mualem, David; Bercovich, Natalia; Stern, Michael Z; Nyambega, Benson; Barda, Omer; Masiga, Dan; Gupta, Sachin K; Michaeli, Shulamit; Levin, Mariano J (Elsevier, 2009-04-01)

  Early in the assembly of the spliceosome of eukaryotes the branch-point binding protein (BBP, also called SF1) recognizes the branch point sequence, whereas the heterodimer U2AF consisting of a 65 and a 35 kDa subunit, ...
• Protein–protein interaction map of the Trypanosoma cruzi ribosomal P protein complex 

  Ayub, Maximiliano J; Smulski, Cristian R; Nyambega, Benson; Bercovich, Natalia; Masiga, Dan; Vazquez, Martín P; Aguilar, Carlos F; Levin, Mariano J (Elsevier, 2005-09-12)

  The large subunit of the eukaryotic ribosome possesses a long and protruding stalk formed by the ribosomal P proteins. Four out of five ribosomal P proteins of Trypanosoma cruzi, TcP0, TcP1α, TcP2α, and TcP2β had been ...
• Molecular characterization of tsetse’s proboscis and its response to Trypanosoma congolense infection 

  Awuoche, Erick O; Weiss, Brian L; Vigneron, Aurélien; Mireji, Paul O; Aksoy, Emre; Nyambega, Benson; Attardo, Geoffrey M; Wu, Yineng; O’Neill, Michelle; Murilla, Grace; Aksoy, Serap (Public Library of Science, 2017)

  Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities ...
• Effect of naturally occurring plant quinones on insect flight muscle mitochondrial respiration 

  Makawiti, DW; Okinji, VN; Magir, En (1997-07-31)
• Olwa-Odyek: Enthnopharmacological screenings of Vernonia amygdalina and Cleome gynandra traditionally used in child birth in Western Uganda 

  Kamatenesi, MM; Makawiti, DW; Origa, H Oryem (2005)
• Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats 

  Konji, Victor N; Olowookere, Julius O; Makawiti, Dominic W; Kamau, John MZ; Kiaira, Job K; Omwandho, Charles A (Springer-Verlag, 1991-07-01)

  Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of ...
• The effect of l-thyroxine on the anaemia response in Trypanosoma congolense infected rabbits 

  Makawiti, Dominic W; Okinji, VN; Lomo, Po (Elsevier, 1995-06-01)

  The development of anaemia is a major pathological manifestation in chronic trypanosomosis. The anaemia in African trypanosomosis coincides with a marked decrease in plasma concentration of both thyroxine (T 4) and 3, ...
• Sehistosoma Mansoni in the Baboon: Modulation of Pathology After Vaccination with Polyclonal Anti‐Idiotypic Antibodies 

  Borus, Pk; Nyindo, M; Farah, IO; Oguya, FO; Makawiti, Dominic W (Blackwell Publishing Ltd, 1995-12-01)

  Vaccination of five baboons with an anti-idiotypic vaccine to irradiated Schistosoma mansoni cercariae resulted in nearly 19% protection compared to 39% protection conferred to five baboons vaccinated with an irradiated ...
• Perception of Academic Staff in Kenyan Public Universities towards Application of Performance Appraisal Results in Training and Promotion decisions 

  Makawiti, Dominic Were (2011-11)

  PERCEPTION OF ACADEMIC STAFF IN KENYAN PUBLIC UNIVERSITIES TOWARDS APPLICATION OF PERFORMANCE APPRAISAL RESULTS IN TRAINING AND PROMOTION DECISIONS DOMINIC WERE MAKAWITI A Management Research Project Submitted in ...
• In vitro interstitial (Leydig) cell response to LH and concentrations of plasma testosterone and LH in the naked mole rat (Heterocephalus glaber, Ruppell) 

  Onyango, DW; GE OTIANGA, OWITI; D ODUOR, OKELO; Makawiti, Dominic W (Blackwell Publishing Ltd, 1991-03-01)

  Summary Reproductive endocrinology of the male naked mole rat (Heterocephalus glaber) caught in the wild was studied. In vitro treatment of isolated Leydig cells using either normal dose of LH capable of stimulating ...
• Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis 

  Kimata, DM; Makawiti, Dominic W; Tengekyon, KM; Dadzie, S; Waindi, EN (Elsevier, 1194-04-01)

  The following indicators of pituitary, adreno-cortical and testicular function were measured in 58 male African trypanosomiasis patients from Western Kenya; plasma cortisol, luteinizing hormone (LH) and testosterone ...
• Thyroid status and adenosine triphosphataseactivity in experimental Trypanosoma congolense infection in rabbits 

  Lomo, Po; Makawiti, Dominic W; Okinji, VN (Saunders, 1996-11-01)

  Summary The effect of trypanosome infection on the plasma levels and ratios of tri- iodothyronine (T 3) and thyroxine (T 4) as well as the activity of mitochondrial adenosine triphosphatase (ATPase) were investigated. ...

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