Department of Medical Biochemistry: Recent submissions
Now showing items 1-20 of 282
-
Association between Human Resource Factors and Utilization of IQCare System for Clinical Decision Support in HIV Care Clinics in Nakuru County, Kenya
(EA Journals, 2023-09-25)Electronic medical records (EMR) are computerized medical information systems that are used to collect, store, and display patient information. EMR systems can strengthen pathways of care and close gaps in patient tracking, ... -
Optimised germination protocol for jackfruit seeds and evaluation of methods for extraction of DNA suitable for genetic analysis
(African Crop Science Society, 2022-08-18)Jackfruit (Artocarpus heterophyllus) is an underutilised plant that is promising in curbing food and nutritional security in sub-Saharan Africa. However, high level of secondary metabolites in its tissues significantly ... -
Genetic diversity and relationships among populations of jackfruit, an underutilized nutrient-rich climate-smart fruit tree crop in Kenya and Uganda
(Taylor & Francis, 2022-09-03)Jackfruit (Artocarpus heterophyllus Lam.) is an underutilized fruit tree crop in East Africa. Despite its importance for food and nutritional security, only limited information exists on the extent of genetic variability ... -
Human NCR3 gene variants rs2736191 and rs11575837 influence susceptibility to the longitudinal development of pediatric severe malarial anemia
(Research square, 2022)Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0g/dL] is the most common clinical manifestation ... -
Immunization of Rabbits with a Quadrivalent Shigella Bioconjugate Vaccine Induces Functional Antibodies Reactive with Shigella Isolates from Kenya
(American Society for Microbiology, 2022)Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although improvements in hygiene and access to clean water are helpful, vaccines ... -
A Comprehensive COVID-19 Daily News and Medical Literature Briefing to Inform Health Care and Policy in New Mexico: Implementation Study
(JMIR Publications Inc., Toronto, Canada, 2022)Background: On March 11, 2020, the New Mexico Governor declared a public health emergency in response to the COVID-19 pandemic. The New Mexico medical advisory team contacted University of New Mexico (UNM) faculty to form ... -
The Potential of Differentiation-Related Gene-1 (DRG1) as a Biomarker for Metastasis of Estrogen Receptor-Positive Breast Cancer
(Journal of Advances in Medicine and Medical Research(JAMMR), 2021)Breast cancer is major burden worldwide and the majority of breast cancers express estrogen receptors (ER) suggesting a high dependence on estrogen hormone. Age is among the major determinants of breast cancer development, ... -
Duffy Antigen/Receptor for Chemokines (DARC): Is There a Role in Prostate Cancer?.
(science direct, 2005)Introduction: The Duffy blood group antigens function as chemokine receptors and as receptors for several species of malarial parasites. Approximately 70% of African Americans are Duffy negative as a result of a single ... -
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia
(Wiley Subscription Services, Inc., A Wiley Company, 2012)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children aged <48 months and manifests as severe malarial anemia [SMA; hemoglobin (Hb) < 6.0 g/dL]. Induction of high levels of ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (− 173) and IFNA8 (− 884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all …
(Springer-Verlag, 2012)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis
(Springer, 2012)Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ... -
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(Springer, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children
(PubMed, 2019)Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. -
2020-04-15 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING
(HSC Institutional and Academic Materials, 2020)NM highlights. Immigration detention centers. US outbreak perceptions. States lockdown protests. Drones sample transport. Black market antivirals. NZ eases lockdown. Germany partial reopening. Low temperature/humidity ... -
Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia
(SAGE Publications, 2021)Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored ... -
Assessment of molecular markers of anti-malarial drug resistance among children participating in a therapeutic efcacy study in western Kenya
(Springer, 2020)Background Anti-malarial drug resistance remains a major threat to global malaria control efforts. In Africa, Plasmodium falciparum remains susceptible to artemisinin-based combination therapy (ACT), but the emergence of ... -
Persistence of oncogenic and non-oncogenic human papillomavirus is associated with human immunodeficiency virus infection in Kenyan women
(Sage, 2020)Objectives: Cervical cancer is caused by persistent infection with oncogenic, or “high-risk” types of human papillomaviruses, and is the most common malignancy in Kenyan women. A longitudinal study was initiated to ... -
Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling
(Elsevier, 2019)ackground: Leukocyte-associated immunoglobulin like receptor-1 (LAIR1) is a transmembrane inhibitory recep- tor that influences susceptibility to a myriad of inflammatory diseases. Our recent investigations of severe ... -
Epidemiological patterns and antimicrobial resistance of bacterial diarrhea among children in Nairobi City, Kenya
(Shahid Beheshti University of Medical Sciences, 2020)Aim: Determine the prevalence of enteric bacterial pathogens and their antimicrobial resistance among diarrheic children in Nairobi City, Kenya. Background: Regardless of enteric bacterial pathogens being a major cause ... -
Distribution of Biomphalaria Snails in Associated Vegetations and Schistosome Infection Prevalence Along the Shores of Lake Victoria in Mbita, Kenya: A Cross-Sectional Study
(East African Health Research Commission, 2019)Background: Schistosomiasis due to Schistosoma mansoni remains a major public health problem and cause of morbidity and mortality in sub-Saharan Africa despite the implementation of control programmes. More than 6 million ...