Browsing Department of Medical Biochemistry by Title
Now showing items 126-145 of 282
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Immunization of Rabbits with a Quadrivalent Shigella Bioconjugate Vaccine Induces Functional Antibodies Reactive with Shigella Isolates from Kenya
(American Society for Microbiology, 2022)Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although improvements in hygiene and access to clean water are helpful, vaccines ... -
Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
(Elsevier, 2015)Background The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporo ... -
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
(Pub Med Central, 2009-11-17)OBJECTIVE: RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis ... -
In vitro evaluation of chloroquine-loaded and heparin surface-functionalized solid lipid nanoparticles
(BioMed Central, 2018-12-01)Use of chloroquine, an otherwise safe and relatively affordable anti-malarial drug, was discontinued due to widespread prevalence of resistant parasites. Many entrant anti-malarial drugs for treatment of chloroquine resistant ... -
In vitro interstitial (Leydig) cell response to LH and concentrations of plasma testosterone and LH in the naked mole rat (Heterocephalus glaber, Ruppell)
(Blackwell Publishing Ltd, 1991-03-01)Summary Reproductive endocrinology of the male naked mole rat (Heterocephalus glaber) caught in the wild was studied. In vitro treatment of isolated Leydig cells using either normal dose of LH capable of stimulating ... -
In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats
(Pergamon, 1995-05-01)Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental ... -
Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya: Implications for the development of severe anemia
(BioMed Central, 2010)Severe anemia due to Plasmodium falciparum malaria is a major cause of mortality among young children in western Kenya. The factors that lead to the age-specific incidence of this anemia are unknown. Previous studies have ... -
INFLUENCE OF DIGITAL MARKETING STRATEGIES ON PERFORMANCE OF CUTFLOWERS EXPORTING FIRMS IN KENYA
(University of Nairobi, Kenya, 2016)Digital marketing is one of the strategies used by firms for marketing communication and products promotion. Digital marketing contributes to the marketing mix by connecting with clients and creating leads to new business ... -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children
(PubMed, 2019)Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in …
(Elsevier, 2019-07-01)Background: Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. Methods: To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome ... -
Interaction of benzoquinones with mitochondria interferes with oxidative phosphorylation characteristics
(University of Nairobi, 1990)Studies with four benzoquinones, viz. juglone, embelin, maesaquinone and maesanin, on rat liver mitochondria oxidative phosphorylation have been carried out. Three of the benzoquinones are uncouplers in the order ... -
Interaction of benzoquinones with mitochondria interferes with oxidative phosphorylation characteristics
(No longer published by Elsevier, 1990-08-06)Studies with four benzoquinones, viz. juglone, embelin, maesaquinone and maesanin, on rat liver mitochondria oxidative phosphorylation have been carried out. Three of the benzoquinones are uncouplers in the order ... -
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(BioMed Central, 2013-12-01)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(BioMed Central, 2013-12)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(Springer, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Internationalization of Higher Education, Africa
(Internationalization of Higher Education, Africa, 2018)Internationalization finds expression through travel abroad by students, faculty engaged in collaborative research and publishing, signing of memoranda of understanding between foreign institutions, when satellite campuses ... -
Is human immunodeficiency virus (HIV) a risk factor to development of dental caries and molar incisor hypomineralization (MIH) in children?
(University of Nairobi, 2015)Introduction: HIV-positive children are susceptible to various infections, and they are often placed on long-term medications to control and/or prevent these infections. It is possible that the ingestion of these medications ... -
Isolation, identification and characterization of urinary tract infectious bacteria and the effect of different antibiotics
(Journal of Natural Sciences Research, 2013)Introduction: Urinary Tract Infection (UTI) defines a condition in which the urinary tract is infected with a pathogen causing inflammation which is a common, distressing and occasionally life threatening condition. UTI ... -
The Kenya haemoglobin.
(East African medical journal, 1974)Haemoglobin Kenya is (at present) a rare haemoglobin variant, found so far only in the Luo tribe in Kenya. It came to light by its chance association with the Hb S trait, a situation giving rise to an unexpectedly high ...