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Safety and immunogenicity of RTS, S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial
(Elsevier, 2016)
Background
Malaria remains a major global public health concern, especially in sub-Saharan Africa. The RTS,S/AS01 malaria candidate vaccine was reviewed by the European Medicines Agency and received a positive scientific ...
Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
(Elsevier, 2015)
Background The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated
with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporo ...
Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children
(BioMed Centra, 2017)
Background: We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the
form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated
ferrous ...
Using health and demographic surveillance systems for teratovigilance in Africa
(Elsevier, 2016)
Increased funding in the past decade has improved healthcare coverage of the population and access to vaccines and drugs across sub-Saharan Africa.1 However, there is still a need to collect valid and sufficient baseline ...
Male partner involvement in efforts to eliminate mother-to-child transmission of HIV in Kisumu County, Western Kenya, 2015
(2017)
Introduction
male partner involvement in elimination of mother-to-child transmission (eMTCT) of HIV activities remains low in Western Kenya, despite its importance in reducing rates of child HIV transmission. We sought ...
Assessing levels and trends of adult mortality in Sub Saharan Africa using INDEPTH health and demographic surveillance systems
(2017)
There is still a considerable dearth of knowledge regarding adult mortality and premature deaths in Sub-Saharan Africa (SSA). Attempts to measure adult mortality using censuses and cross-sectional surveys rely mainly on ...
Health & demographic surveillance system profile: the Kombewa health and demographic surveillance system (Kombewa HDSS)
(Oxford University Press, 2014)
The Kombewa Health and Demographic Surveillance System (HDSS) grew out of the Kombewa Clinical Research Centre in 2007 and has since established itself as a platform for the conduct of regulated clinical trials, nested ...
Association between sickle cell trait and low density parasitaemia in a P. falciparum malaria holoendemic region of Western Kenya
(University of Nairobi Institute of Tropical & Infectious Diseases (UNITID), Kenya, 2012)
Aims: The frequency of the mutant gene for sickle cell is widely distributed in the sub- Saharan Africa, the Middle East, and the Indian subcontinent. There is epidemiologic
evidence that sickle cell trait confers a ...
Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study
(spring link, 2014)
Background
Alternatives to treatment for malaria treatment of travellers are needed in the USA and in Europe for travellers who return with severe malaria infections. The objective of this study is to show the pharmacokinetic ...
The Levels of CD16/Fcγ Receptor IIIA on CD14+ CD16+ Monocytes Are Higher in Children with Severe Plasmodium falciparum Anemia than in Children with Cerebral or Uncomplicated Malaria
(American Society for Microbiology Journals, 2010)
Fc gamma receptor IIIA (CD16/FcγRIIIA) on monocytes/macrophages may play an important role in the pathogenesis of severe malarial anemia (SMA) by promoting phagocytosis of IgG-coated uninfected red cells and by allowing ...