Browsing Department of Medical Biochemistry by Title
Now showing items 116-135 of 282
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Haemostatic disorders in patients with breast cancer at Kenyatta national hospital, Kenya
(University of Nairobi, 2010)Haemostatic disorders (thrombosis and haemorrhage) are increasingly being investigated and assessed as factors that influence outcome of treatment of solid tumors including breast cancer. There is little data available on ... -
Haplotypes and α globin gene analyses in sickle cell anaemia patients from Kenya
(Blackwell Publishing Ltd, 1987-02)Over 60 patients from the Luo and Luhya tribes of Western Kenya, aged 1–23 years. with severe sickle cell anaemia were evaluated through haematological and gene mapping analyses. Nearly all (56 of 58 tested) were homozygous ... -
Health & demographic surveillance system profile: the Kombewa health and demographic surveillance system (Kombewa HDSS)
(Oxford University Press, 2014)The Kombewa Health and Demographic Surveillance System (HDSS) grew out of the Kombewa Clinical Research Centre in 2007 and has since established itself as a platform for the conduct of regulated clinical trials, nested ... -
Health care seeking behavior among caregivers of sick children who 2 had severe malarial anaemia 3
(maseno university, 2015)Aims: The western region in Kenya is holoendemic to malaria and experience stable P. falciparum malaria transmission. The use of health care options has a direct influence on the outcome of severe malaria. As such, the ... -
Health literacy knowledge and experience of bachelor nursing students at a university in the Western Cape
(University of the Western Cape, 2016)Background: Health literacy is defined as the degree to which an individual has the capacity of obtaining, processing, and understanding basic health information and services needed for one to make appropriate decisions ... -
Hemifacial spasm: case report
(Kenya Medical Association, 2006-07)A 53 year old lady with diabetes mellitus presented with right hemi-facial spasm (HFS). Brain MRI Scan revealed extensive pan-sinusitis and mild bilateral mastoiditis. She responded well to intravenous ceftriaxone therapy ... -
Hemoglobin Kenya, the product of a gamma-beta fusion gene: studies of the family.
(Elsevier, 1973-09)Recently, we reported the discovery of a new hemoglobin variant, Hb Kenya, in a 26-year-old Kenyan of the Nilotic Luo tribe [1]. Chemical characterization of the non-a chain of this hemoglobin showed that the amino ... -
HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort
(Springer Berlin Heidelberg, 2014-02-01)In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection ... -
Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
(Nature Publishing Group, 2018)Host immunity exerts strong selective pressure on pathogens. Population-level genetic analysis can identify signatures of this selection, but these signatures reflect the net selective effect of all hosts and vectors in a ... -
Human NCR3 gene variants rs2736191 and rs11575837 influence susceptibility to the longitudinal development of pediatric severe malarial anemia
(Research square, 2022)Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0g/dL] is the most common clinical manifestation ... -
Immunization of Rabbits with a Quadrivalent Shigella Bioconjugate Vaccine Induces Functional Antibodies Reactive with Shigella Isolates from Kenya
(American Society for Microbiology, 2022)Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although improvements in hygiene and access to clean water are helpful, vaccines ... -
Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
(Elsevier, 2015)Background The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporo ... -
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
(Pub Med Central, 2009-11-17)OBJECTIVE: RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis ... -
In vitro evaluation of chloroquine-loaded and heparin surface-functionalized solid lipid nanoparticles
(BioMed Central, 2018-12-01)Use of chloroquine, an otherwise safe and relatively affordable anti-malarial drug, was discontinued due to widespread prevalence of resistant parasites. Many entrant anti-malarial drugs for treatment of chloroquine resistant ... -
In vitro interstitial (Leydig) cell response to LH and concentrations of plasma testosterone and LH in the naked mole rat (Heterocephalus glaber, Ruppell)
(Blackwell Publishing Ltd, 1991-03-01)Summary Reproductive endocrinology of the male naked mole rat (Heterocephalus glaber) caught in the wild was studied. In vitro treatment of isolated Leydig cells using either normal dose of LH capable of stimulating ... -
In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats
(Pergamon, 1995-05-01)Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental ... -
Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya: Implications for the development of severe anemia
(BioMed Central, 2010)Severe anemia due to Plasmodium falciparum malaria is a major cause of mortality among young children in western Kenya. The factors that lead to the age-specific incidence of this anemia are unknown. Previous studies have ... -
INFLUENCE OF DIGITAL MARKETING STRATEGIES ON PERFORMANCE OF CUTFLOWERS EXPORTING FIRMS IN KENYA
(University of Nairobi, Kenya, 2016)Digital marketing is one of the strategies used by firms for marketing communication and products promotion. Digital marketing contributes to the marketing mix by connecting with clients and creating leads to new business ... -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children
(PubMed, 2019)Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in …
(Elsevier, 2019-07-01)Background: Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. Methods: To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome ...