Browsing Department of Medical Biochemistry by Title

Now showing items 109-128 of 282

    • GalAactosaemia in black South African children 

      PJ Ojwang; T Manickum; WM Deppe (Kenya Medical Association, 1999)
      To evaluate the clinical and biochemical features of all black children confirmed to have galactosaemia from the KwaZulu Natal Province of South Africa.

    • Genetic analysis of HIV-1 subtypes in Nairobi, Kenya 

      Suhail Khoja, Peter Ojwang, Saeed Khan, Nancy Okinda, Reena Harania, Syed Ali (Public Library of Science, 2008-09-11)
      Genetic analysis of a viral infection helps in following its spread in a given population, in tracking the routes of infection and, where applicable, in vaccine design. Additionally, sequence analysis of the viral genome ...

    • Genetic diversity and protective efficacy of the RTS, S/AS01 malaria vaccine 

      Daniel E Neafsey, Michal Juraska, Trevor Bedford, David Benkeser, Clarissa Valim, Allison Griggs, Marc Lievens, Salim Abdulla, Samuel Adjei, Tsiri Agbenyega, Selidji T Agnandji, Pedro Aide, Scott Anderson, Daniel Ansong, John J Aponte, Kwaku Poku Asante, Philip Bejon, Ashley J Birkett, Myriam Bruls, Kristen M Connolly, Umberto D’Alessandro, Carlota Dobaño, Samwel Gesase, Brian Greenwood, Jonna Grimsby, Halidou Tinto, Mary J Hamel, Irving Hoffman, Portia Kamthunzi, Simon Kariuki, Peter G Kremsner, Amanda Leach, Bertrand Lell, Niall J Lennon, John Lusingu, Kevin Marsh, Francis Martinson, Jackson T Molel, Eli L Moss, Patricia Njuguna, Christian F Ockenhouse, Bernhards Ragama Ogutu, Walter Otieno, Lucas Otieno, Kephas Otieno, Seth Owusu-Agyei, Daniel J Park, Karell Pellé, Dana Robbins, Carsten Russ, Elizabeth M Ryan, Jahit Sacarlal, Brian Sogoloff, Hermann Sorgho, Marcel Tanner, Thor Theander, Innocent Valea, Sarah K Volkman, Qing Yu, Didier Lapierre, Bruce W Birren, Peter B Gilbert, Dyann F Wirth (Massachusetts Medical Society, 2015)
      BACKGROUND The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated ...

    • Genetic diversity and relationships among populations of jackfruit, an underutilized nutrient-rich climate-smart fruit tree crop in Kenya and Uganda 

      OJWANG, Redemtor Awuor; MUGE, Edward K; NYABOGA, Evans N; MBATIA, Betty N; OGOYI, Dorington O (Taylor & Francis, 2022-09-03)
      Jackfruit (Artocarpus heterophyllus Lam.) is an underutilized fruit tree crop in East Africa. Despite its importance for food and nutritional security, only limited information exists on the extent of genetic variability ...

    • The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis 

      Douglas J Perkins, Tom Were, Samuel Anyona, James B Hittner, Prakasha Kempaiah, Gregory C Davenport, John Michael Ong’echa (Springer, New York, NY, 2013)
      Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ...

    • The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis 

      Douglas J. PerkinsEmail authorTom WereSamuel AnyonaJames B. HittnerPrakasha KempaiahGregory C. DavenportJohn Michael Ong’echa (Springer, 2012)
      Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ...

    • A global" School for Surgeons" could help bridge the Healthcare Human Resource Crisis in Sub-Saharan Africa 

      STEPHEN OGENDO, SWO Ogendo (University of Nairobi, 2009)
      Appropriately designed elearning programmes (including Best or School for Surgeons) may allow more efficient use of consultant teaching time. Using funding from Irish Aid, we piloted these existing e-learning tools in a ...

    • Haemostatic disorders in patients with breast cancer at Kenyatta national hospital, Kenya 

      Peter K Asaava (University of Nairobi, 2010)
      Haemostatic disorders (thrombosis and haemorrhage) are increasingly being investigated and assessed as factors that influence outcome of treatment of solid tumors including breast cancer. There is little data available on ...

    • Haplotypes and α globin gene analyses in sickle cell anaemia patients from Kenya 

      Unknown author (Blackwell Publishing Ltd, 1987-02)
      Over 60 patients from the Luo and Luhya tribes of Western Kenya, aged 1–23 years. with severe sickle cell anaemia were evaluated through haematological and gene mapping analyses. Nearly all (56 of 58 tested) were homozygous ...

    • Health & demographic surveillance system profile: the Kombewa health and demographic surveillance system (Kombewa HDSS) 

      Peter Sifuna, Mary Oyugi, Bernhards Ogutu, Ben Andagalu, Allan Otieno, Victorine Owira, Nekoye Otsyula, Janet Oyieko, Jessica Cowden, Lucas Otieno, Walter Otieno (Oxford University Press, 2014)
      The Kombewa Health and Demographic Surveillance System (HDSS) grew out of the Kombewa Clinical Research Centre in 2007 and has since established itself as a platform for the conduct of regulated clinical trials, nested ...

    • Health care seeking behavior among caregivers of sick children who 2 had severe malarial anaemia 3 

      Stacey MO Gondi, Collins Ouma, Harrysone Atieli, Walter Otieno (maseno university, 2015)
      Aims: The western region in Kenya is holoendemic to malaria and experience stable P. falciparum malaria transmission. The use of health care options has a direct influence on the outcome of severe malaria. As such, the ...

    • Health literacy knowledge and experience of bachelor nursing students at a university in the Western Cape 

      Francesca Chepkemoi Mibei (University of the Western Cape, 2016)
      Background: Health literacy is defined as the degree to which an individual has the capacity of obtaining, processing, and understanding basic health information and services needed for one to make appropriate decisions ...

    • Hemifacial spasm: case report 

      JO Jowi, J Matende, MI Macharia (Kenya Medical Association, 2006-07)
      A 53 year old lady with diabetes mellitus presented with right hemi-facial spasm (HFS). Brain MRI Scan revealed extensive pan-sinusitis and mild bilateral mastoiditis. She responded well to intravenous ceftriaxone therapy ...

    • Hemoglobin Kenya, the product of a gamma-beta fusion gene: studies of the family. 

      AG Kendall, PJ Ojwang, WA Schroeder, TH Huisman (Elsevier, 1973-09)
      Recently, we reported the discovery of a new hemoglobin variant, Hb Kenya, in a 26-year-old Kenyan of the Nilotic Luo tribe [1]. Chemical characterization of the non-a chain of this hemoglobin showed that the amino ...

    • HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort 

      Syed Hani Abidi, Aniqa Shahid, Laila S Lakhani, Reena Shah, Nancy Okinda, Peter Ojwang, Farhat Abbas, Sarah Rowland-Jones, Syed Ali (Springer Berlin Heidelberg, 2014-02-01)
      In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection ...

    • Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections 

      ngela M Early, Marc Lievens, Bronwyn L MacInnis, Christian F Ockenhouse, Sarah K Volkman, Samuel Adjei, Tsiri Agbenyega, Daniel Ansong, Stacey Gondi, Brian Greenwood, Mary Hamel, Chris Odero, Kephas Otieno, Walter Otieno, Seth Owusu-Agyei, Kwaku Poku Asante, Hermann Sorgho, Lucas Tina, Halidou Tinto, Innocent Valea, Dyann F Wirth, Daniel E Neafsey (Nature Publishing Group, 2018)
      Host immunity exerts strong selective pressure on pathogens. Population-level genetic analysis can identify signatures of this selection, but these signatures reflect the net selective effect of all hosts and vectors in a ...

    • Human NCR3 gene variants rs2736191 and rs11575837 influence susceptibility to the longitudinal development of pediatric severe malarial anemia 

      Onyango Clinton O, Qiuying Cheng, Elly O Munde, Evans Raballah, Samuel B Anyona, Benjamin H McMahon, Christophe G Lambert, Patrick O Onyango, Kristan A Schneider, Douglas J Perkins, Collins Ouma (Research square, 2022)
      Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0g/dL] is the most common clinical manifestation ...

    • Immunization of Rabbits with a Quadrivalent Shigella Bioconjugate Vaccine Induces Functional Antibodies Reactive with Shigella Isolates from Kenya 

      Odundo, A Elizabeth , Hailey P Weerts, Lillian Musila, Lilian Ogonda, Anita M Dreyer, Joerg Schneider, Paula Carranza, Robert W Kaminski (American Society for Microbiology, 2022)
      Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although improvements in hygiene and access to clean water are helpful, vaccines ...

    • Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial 

      Michael T White, Robert Verity, Jamie T Griffin, Kwaku Poku Asante, Seth Owusu-Agyei, Brian Greenwood, Chris Drakeley, Samwel Gesase, John Lusingu, Daniel Ansong, Samuel Adjei, Tsiri Agbenyega, Bernhards Ogutu, Lucas Otieno, Walter Otieno, Selidji T Agnandji, Bertrand Lell, Peter Kremsner, Irving Hoffman, Francis Martinson, Portia Kamthunzu, Halidou Tinto, Innocent Valea, Hermann Sorgho, Martina Oneko, Kephas Otieno, Mary J Hamel, Nahya Salim, Ali Mtoro, Salim Abdulla, Pedro Aide, Jahit Sacarlal, John J Aponte, Patricia Njuguna, Kevin Marsh, Philip Bejon, Eleanor M Riley, Azra C Ghani (Elsevier, 2015)
      Background The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporo ...

    • Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial. 

      Waitumbi, JN; Anyona, SB; Hunja, CW; Kifude, CM; Polhemus, ME; Walsh, DS; Ockenhouse, CF; Heppner, DG; Leach, A; Lievens, M; Ballou, WR; Cohen, JD; Sutherland, CJ (Pub Med Central, 2009-11-17)
      OBJECTIVE: RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis ...