Browsing Department of Medical Biochemistry by Title
Now showing items 46-65 of 282
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COMPLEMENT REGULATORY PROTEIN LEVELS IN CHILDREN WITH SICKLE CELL TRAIT
(Nairobi university, 2009)Sickle cell disease refers to a collection of autosomal recessive genetic disorders characterized by the presence of HbS variant of the globin chain while “sickle cell anaemia” refers to individuals with two copies of the ... -
Complete blood count reference intervals from a healthy adult urban population in Kenya
(Public Library of Science, 2018-06-07)There are racial, ethnic and geographical differences in complete blood count (CBC) blood count (CBC) and therefore it is necessary to establish RIs that are population specific. Several studies have been carried out in ... -
A Comprehensive COVID-19 Daily News and Medical Literature Briefing to Inform Health Care and Policy in New Mexico: Implementation Study
(JMIR Publications Inc., Toronto, Canada, 2022)Background: On March 11, 2020, the New Mexico Governor declared a public health emergency in response to the COVID-19 pandemic. The New Mexico medical advisory team contacted University of New Mexico (UNM) faculty to form ... -
Correlates of post loop Electrosurgical Excision Procedure (LEEP) Recurrence of Cervical Intra epithelical Neoplasia
(University of Nairobi, Kenya, 2011)Background: Cervical cancer is the commonest gynaecological malignancy worldwide, with an increased burden of disease in developing countries. Effective cytological screening and follow up intervention programs have been ... -
A critical view of pharmacy education and practice in Kenya
(InPharm, 2017)2. PharmD/MBA, PharmD/MPH dual degrees should be introduced. Students keen on careers in business or administration would naturally be drawn to the former while those with an interest in epidemiological research would lean ... -
Cryptococcus Meningitis in a Cohort of HIV Positive Kenyan Patients: Outcome after Two Weeks of Therapy
(East African Medical Journal, 2013)Background: Cryptococcus meningitis is the most lethal meningitis in patients with HIV/AIDS. It is invariably fatal if not treated appropriately and promptly. In sub- Saharan Africa with the highest prevalence of HIV/AIDS, ... -
Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children
(BioMed Centra, 2017)Background: We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous ... -
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats
(Springer-Verlag, 1991-07-01)Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of ... -
Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis
(Elsevier, 2018)The following indicators of pituitary, adreno-cortical and testicular function were measured in 58 male African trypanosomiasis patients from Western Kenya; plasma cortisol, luteinizing hormone (LH) and testosterone ... -
Depletion of trypanosome CTR9 leads to gene expression defects
(Public Library of Science, 2012-04-20)The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA ... -
Determinants of adherence to anti-retroviral therapy among discordant couples in Usigu Division, Bondo sub-county, Kenya
(Kenya Medical Association, 2018)Objective: To establish the determinants of adherence to ART among discordant couples in Usigu Division, Bondo sub-County. Design: A descriptive cross-sectional study. Setting: Comprehensive Care Clinics within Usigu ... -
Determinants of antibiotic dose adjustment in patients with chronic kidney disease at Kenyatta National Hospital Kenya
(University of Nairobi, 2014)Background: Reduced renal function in chronic kidney disease (CKD) necessitates appropriate dose alterations to avoid drug accumulation. Objectives: The main objective of the study was to determine the prevalence of ... -
Determinants of Appropriate Antibiotic Dosing in Patients with Chronic Kidney Disease in a Kenyan Referral Hospital
(A KeSoBAP Publication, 2014-12-05)Background: Reduced renal function in chronic kidney disease (CKD) necessitates appropriate dose alterations to avoid drug accumulation. Objectives: The main objective of the study was to determine the prevalence of ... -
Determinants of quality of life among gynaecological cancer patients on follow up at a referral hospital in Kenya
(University of Nairobi, 2015-06-08)Various factors influence the quality of life (QOL) in cancer patients. This study sought to determine the predictors and factors associated with quality of life among g ynaecological cancer patients on follow up at Kenya ... -
Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods
(Public Library of Science, 2020-07-09)Due to a lack of reliable reference intervals (RIs) for Kenya, we set out to determine RIs for 40 common chemistry and immunoassay tests as part of the IFCC global RI project. -
Diagnostic dose determination and efficacy of chlorfenapyr and clothianidin insecticides against Anopheles malaria vector populations of western Kenya
(BioMed Central, 2019)Background: Malaria vector control is dependent on chemical insecticides applied to walls by indoor residual spraying or on long-lasting insecticidal nets. The emergence and spread of insecticide resistance in major malaria ... -
The differential effect of the free maternity services policy in Kenya
(AOSIS Publishing, 2019)BACKGROUND: The Government of Kenya introduced the free maternity services (FMS) policy to enable mothers deliver at a health facility and thus improve maternal health indicators. AIM: The aim of this study was to determine ... -
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide
(Nature Publishing Group, 2019-04-17)Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ... -
Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia
(Blackwell Publishing Ltd, 2008)Plasmodium falciparum infection can lead to deadly complications such as severe malaria‐associated anaemia (SMA) and cerebral malaria (CM). Children with severe malaria have elevated levels of circulating immune complexes ...