Browsing Department of Medical Biochemistry by Title
Now showing items 25-44 of 282
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Association between sickle cell trait and low density parasitaemia in a P. falciparum malaria holoendemic region of Western Kenya
(University of Nairobi Institute of Tropical & Infectious Diseases (UNITID), Kenya, 2012)Aims: The frequency of the mutant gene for sickle cell is widely distributed in the sub- Saharan Africa, the Middle East, and the Indian subcontinent. There is epidemiologic evidence that sickle cell trait confers a ... -
The Benefits of research partnerships to the community at KEMRI/Walter Reed Project
(Dspace, 2015)Ethical Principles on Human Subject Protection in Clinical Research revolves around Autonomy, Beneficence and Justice. Beneficence requires that the benefits to research participants are maximized as you minimize the risk ... -
beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya.
(East African medical journal, 1989)In this paper, we present data on studies of beta S-haplotypes and alpha-thalassemia gene in subjects from the indigenous population of the Coast Province of Kenya Of the 7SS patients studied, four were homozygous for beta ... -
Biochemical and molecular diagnosis of glutaric aciduria type 1 in a black South African male child: case report
(East African medical journal, 2001)Glutaric aciduria type I (GA-1) is an inborn error of metabolism caused by a deficiency of the mitochondrial enzyme glutaryl-Co enzyme A dehydrogenase. GA-1 is not uncommon amongst Caucasians but to the best of our knowledge, ... -
Bullous erythema multiforme after treatment with Malarone®, a combination antimalarial composed of atovaquone and proguanil hydrochloride
(SAGE Publications, 2008)We report on a Kenyan woman who developed bullous erythema multiforme, in association with Malarone treatment. -
Cardiovascular risk factors among people living with HIV in rural Kenya: a clinic-based study
(Clinics Cardive Publishing, 2019-07-01)Objectives: To determine the prevalence of cardiovascular risk factors and their association with antiretroviral therapy (ART) among HIV-infected adults in a rural sub-county hospital in Kenya. Methods: This was a ... -
Case Management of Substance Induced Psychosis Using Peplau’s Theory of Interpersonal Relations
(2017)Substance induced psychosis is a form of psychosis that develops from the use of alcohol or other drugs. The symptoms for this form of psychosis can resolve within days or weeks though tendencies of relapsing occur with ... -
Changes in plasma HDL-cholesterol in women using oral contraceptives in Kenya
(University of Nairobi., 1987)125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: ... -
Changes in the concentrations of testosterone, luteinising hormone and progesterone associated with administration of embelin
(Elsevier, 1991-10-01)The mode of action of embelin, a naturally occurring plant benzoquinone with male fertility regulating potential, was investigated. Sexually mature white New Zealand male rabbits were injected intra-muscularly with ... -
Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study)
(Oxford University Press, 2015)Aims Rheumatic heart disease (RHD) accounts for over a million premature deaths annually; however, there is little contemporary information on presentation, complications, and treatment. Methods and results This ... -
Characterization of chromosomes with hybrid genes for Hb Lepore-Washington, Hb Lepore-Baltimore, Hb P-Nilotic, and Hb Kenya
(Springer-Verlag, 1987-09-01)This study concerns the characterization of chromosomes with hybrid genes for Hb Lepore-Washington (44 chromosomes), for Hb Lepore-Baltimore (5 chromosomes), for Hb P-Nilotic (8 chromosomes), and for Hb Kenya (7 chromosomes) ... -
Clinical and laboratory characteristics of hospitalised patients with neurological manifestations of HIV/AIDS at the Nairobi hospital
(East African Medical Journal, 2007)Objective: To determine the profile of clinical and laboratory characteristics of hospitalised HIV positive patients with neurological complications at a private hospital in Nairobi, Kenya from Ianuary 2000 to June ... -
Clinical and molecular evidence for a case of Buruli ulcer (Mycobacterium ulcerans infection) in Kenya
(The American Society of Tropical Medicine and Hygiene, 2009)Mycobacterium ulcerans infection is an emerging disease that causes indolent, necrotizing skin lesions known as Buruli ulcer (BU) and occasional contiguous or metastatic bone lesions. Buruli ulcer is named after Buruli ... -
Clinical outcomes in 3343 children and adults with rheumatic heart disease from 14 low-and middle-income countries: two-year follow-up of the Global Rheumatic Heart Disease …
(Lippincott Williams & Wilkins, 2017-11-08)BACKGROUND:There are few contemporary data on the mortality and morbidity associated with rheumatic heart disease or information on their predictors. We report the 2-year follow-up of individuals with rheumatic heart disease ... -
Community participation in integrated water, sanitation & hygiene (WASH) programs in supply of safe water in Trans Nzioa, Kenya
(international knowledge sharing platform, 2014)37% of Developing world’s population lack access to clean water; 2.5 billion people lack improved basic sanitation and hygiene facilities, over 780 million people still use unsafe drinking water. Trans Nzioa County, ... -
Comparison of 60mg and 40mg doses of hyoscine butylbromide on labor outcomes at Moi teaching and referral hospital, Eldoret, Kenya
(Research gate, 2014)Introduction: Effects of 40mg of Hyoscine butylbromide (HBB) in reducing duration of active phase of labor are well documented. However effects of 60mg have not been well studied despite the fact that it is often ... -
A comparison of all-cause and cause-specific mortality by household socioeconomic status across seven INDEPTH network health and demographic surveillance systems in sub-Saharan Africa
(Taylor & FrancisTaylor & Francis, 2019)ABSTRACT Background: Understanding socioeconomic disparities in all-cause and cause-specific mortality can help inform prevention and treatment strategies. Objectives: To quantify cause-specific mortality rates by ... -
Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study
(BioMed Central, 2017-12)Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of ... -
Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia
(SAGE Publications, 2021)Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored ...