Department of Medical Biochemistry: Recent submissions

Now showing items 221-240 of 282

    • Seven key actions to eradicate rheumatic heart disease in Africa: the Addis Ababa communiqué: cardiovascular topics 

      Mohammed Al-Kebsi, Azza Abul-Fadl, Mark Engel, Ana Olga Mocumbi, Steve Justus, Gasnat Shaboodien, Bernard Gitura, Alaa Elghamrawy, Joris Van Dam, Abraha Hailu, Liesl Zuhlke, Dike Ojji, George Nel, Elijah Ogola, Diana Lennon, John Musuku, Pindile Mntla, Abiodun Adeoye, Christopher Hugo-Hamman, David Watkins, Albertino Damasceno, Louis Murango, Charles Mondo, Mabvuto Kango, Ganesan Karthikeyan, Jonathan Carapetis, Stephen Ogendo, Mahmoud Sani, Steven Shongwe, Agnes Mtaja, Kamanzi Emmanuel Rusingiza, Fidelia Bode-Thomas, Yoseph Mamo, Sahar Sheta, Mekia Mohammed Redi, Rezeen Daniels, Bongani M Mayosi, Gene Bukhman, Joseph Mucumbitsi, Veronica Francis, Sulafa Ali, Habib Gamra, Abraham Haileamlak, Peter Lwabi, Chris Sutton, Taiwo Olabisi Olunuga, Neil Kennedy, Dejuma Yadeta Goshu (Sabinet, 2016-05-01)
      Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) remain major causes of heart failure, stroke and death among African women and children, despite being preventable and imminently treatable. From 21 to 22 ...

    • Clinical outcomes in 3343 children and adults with rheumatic heart disease from 14 low-and middle-income countries: two-year follow-up of the Global Rheumatic Heart Disease … 

      Liesl Zühlke, Ganesan Karthikeyan, Mark E Engel, Sumathy Rangarajan, Pam Mackie, Blanche Cupido-Katya Mauff, Shofiqul Islam, Rezeen Daniels, Veronica Francis, Stephen Ogendo, Bernard Gitura, Charles Mondo, Emmy Okello, Peter Lwabi, Mohammed M Al-Kebsi, Christopher Hugo-Hamman, Sahar S Sheta, Abraham Haileamlak, Wandimu Daniel, Dejuma Yadeta Goshu, Senbeta G Abdissa, Araya G Desta, Bekele A Shasho, Dufera M Begna, Ahmed ElSayed, Ahmed S Ibrahim, John Musuku, Fidelia Bode-Thomas, Christopher C Yilgwan, Ganiyu A Amusa, Olukemi Ige, Basil Okeahialam, Christopher Sutton, Rajeev Misra, Azza Abul Fadl, Neil Kennedy, Albertino Damasceno, Mahmoud U Sani, Okechukwu S Ogah, Taiwo OlunugaHuda HM Elhassan, Ana Olga Mocumbi, Abiodun M Adeoye, Phindile Mntla, Dike Ojji, Joseph Mucumbitsi, Koon Teo, Salim Yusuf, Bongani M Mayosi (Lippincott Williams & Wilkins, 2017-11-08)
      BACKGROUND:There are few contemporary data on the mortality and morbidity associated with rheumatic heart disease or information on their predictors. We report the 2-year follow-up of individuals with rheumatic heart disease ...

    • Prevalence, Progression and Associated Risk Factors of Asymptomatic Peripheral Arterial Disease 

      Nikita Mehta, Stephen Ogendo, Mark Awori (The Surgical Society of Kenya, 2017)
      Introduction: The prevalence of peripheral arterial disease (PAD) ranges between 4.5% and 57% and is independently associated with cardiovascular disease burden irrespective of symptoms. Two thirds of cases are thought to ...

    • Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study 

      Bruce M Biccard, Thandinkosi E Madiba, Hyla-Louise Kluyts, Dolly M Munlemvo, Farai D Madzimbamuto, Apollo Basenero, Christina S Gordon, Coulibaly Youssouf, Sylvia R Rakotoarison, Veekash Gobin, Ahmadou L Samateh, Chaibou M Sani, Akinyinka O Omigbodun, Simbo D Amanor-Boadu, Janat T Tumukunde, Tonya M Esterhuizen, Yannick Le Manach, Patrice Forget, Abdulaziz M Elkhogia, Ryad M Mehyaoui, Eugene Zoumeno, Gabriel Ndayisaba, Henry Ndasi, Andrew KN Ndonga, Zipporah WW Ngumi, Ushmah P Patel, Daniel Zemenfes Ashebir, Akwasi AK Antwi-Kusi, Bernard Mbwele, Hamza Doles Sama, Mahmoud Elfiky, Maher A Fawzy, Rupert M Pearse, Hippolyte Abadagan, N Abbas, A Ibrahim Abdelatif, Traoré Abdoulaye, A Abd-rouf, A Abduljalil, A Abdulrahman, S Abdurazig, A Abokris, W Abozaid, SOA Abugassa, F Abuhdema, SA Abujanah, R Abusamra, A Abushnaf, SA Abusnina, TS Abuzalout, HM Ackermann, YB Adamu, A Addanfour, DM Adeleke, TA Adigun, AO Adisa, Sèhivè Valéry Adjignon, NA Adu-Aryee, BB Afolabi, AFX Agaba, PKA Agaba, K Aghadi, H Agilla, B Ahmed, El-Z Ahmed, Al-J Ahmed, M Ahmed, Rene Ahossi, SA Aji, S Akanyun, I Akhideno, M Akhter, OA Akinyemi, M Akkari, Joseph Akodjenou, AL AL Samateh, ES al Shams, OT Alagbe-Briggs, EA Alakkari, RB Alalem, M Alashhab, OI Alatise, A Alatresh, MSI Alayeb Alayeb, BA Albakosh, F Albert, ANJD Alberts, AD Aldarrat, A Alfari, A Alfetore, M Algbali, A Algddar, HA Algedar, IA Alghafoud, A Alghazali, M Alhajj, A Alhendery Alhendery, FFH Alhoty, A Ali, YA Ali, Beye Seïdina Alioune, MA Alkassem, MA Alkchr, TS Alkesa, A Alkilani, F Alkobty Alkobty, Thomas Allaye, SBM Alleesaib, A Alli, K Allopi, NL Allorto, A Almajbery, R Almesmary, SHA Almisslati, F Almoraid, H Alobeidi, MA Alomami, Christella S Alphonsus, OA Alqawi, AA Alraheem, SA Alsabri, A Alsayed, B Alsellabi, M Al-Serksi, MSA Alshareef, AA Altagazi, JS Aluvale, HW Alwahedi, EA Alzahra, MA Alzarouk, K Al-Zubaidy, Maiga Amadou, Maiga Amadou, Al-A Amer, BT Amisi, MA Amuthenu, TWA Anabah, Felix Anani, PGR Anderson, AGB Andriamampionona, L Andrianina, A Anele, R Angelin, N Anjar, O Antùnez, Akwasi Antwi-Kusi, LJC Anyanwu, AA Aribi, OA Arowolo, O Arrey (Elsevier, 2018-04-21)
      There is a need to increase access to surgical treatments in African countries, but perioperative complications represent a major global health-care burden. There are few studies describing surgical outcomes in ...

    • Employment Cost Index, Historical Listing–Volume V: Continuous Occupational and Industry Series: September 1975-December 2017. Table 4: employment cost index for total … 

      Emelia J Benjamin, Paul Muntner, Alvaro Alonso, Marcio S Bittencourt, Clifton W Callaway, April P Carson, Alanna M Chamberlain, Alexander R Chang, Susan Cheng, Sandeep R Das, Francesca N Delling, Luc Djousse, Mitchell SV Elkind, Jane F Ferguson, Myriam Fornage, Lori Chaffin Jordan, Sadiya S Khan, Brett M Kissela, Kristen L Knutson, Tak W Kwan, Daniel T Lackland, Tené T Lewis, Judith H Lichtman, Chris T Longenecker, Matthew Shane Loop, Pamela L Lutsey, Seth S Martin, Kunihiro Matsushita, Andrew E Moran, Michael E Mussolino, Martin O’Flaherty, Ambarish Pandey, Amanda M Perak, Wayne D Rosamond, Gregory A Roth, Uchechukwu KA Sampson, Gary M Satou, Emily B Schroeder, Svati H Shah, Nicole L Spartano, Andrew Stokes, David L Tirschwell, Connie W Tsao, Mintu P Turakhia, Lisa B VanWagner, John T Wilkins, Sally S Wong, Salim S Virani, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee, American Heart Association, US Census Bureau population estimates: historical data: 2000s, Centers for Disease Control and Prevention, National Center for Health Statistics, World Health Organization, National Center for Health Statistics, Centers for Medicare and Medicaid Services, RN Anderson, HM Rosenberg, World Health Organization, DM Lloyd-Jones, Y Hong, D Labarthe, D Mozaffarian, LJ Appel, L Van Horn, K Greenlund, S Daniels, G Nichol, GF Tomaselli, DK Arnett, GC Fonarow, PM Ho, MS Lauer, FA Masoudi, RM Robertson, V Roger, LH Schwamm, P Sorlie, CW Yancy, WD Rosamond, American Heart Association Strategic Planning Task Force and Statistics Committee, American Heart Association, JS Rumsfeld, KP Alexander, DC Goff Jr, MM Graham, PM Ho, FA Masoudi, DK Moser, VL Roger, MS Slaughter, KG Smolderen, JA Spertus, MD Sullivan, D Treat-Jacobson, JJ Zerwic, American Heart Association Council on Quality of Care and Outcomes Research, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, and Stroke Council, CM Shay, HS Gooding, R Murillo, R Foraker, Y Chang, X Guo, Y Chen, L Guo, Z Li, S Yu, H Yang, G Sun, Y Sun, T Laitinen, TT Laitinen, K Pahkala, CG Magnussen, M Oikonen, JS Viikari, MA Sabin, SR Daniels, OJ Heinonen, L Taittonen, O Hartiala, V Mikkilä, N Hutri-Kähönen, T Laitinen, M Kähönen, OT Raitakari, M Juonala, A Younus, EC Aneni, ES Spatz, CU Osondu, L Roberson, O Ogunmoroti, R Malik, SS Ali, M Aziz, T Feldman, SS Virani, W Maziak, AS Agatston, E Veledar, K Nasir, L Zhou, L Zhao, Y Wu, Y Wu, X Gao, Y Li, J Mai, Z Nie, Y Ou (RTI International, 2019-05-05)
      Each year, the American Heart Association (AHA), in conjunction with the National Institutes of Health and other government agencies, brings together in a single document the most up-to-date statistics related to heart ...

    • Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study 

      David Bishop, Robert A Dyer, Salome Maswime, Reitze N Rodseth, Dominique van Dyk, Hyla-Louise Kluyts, Janat T Tumukunde, Farai D Madzimbamuto, Abdulaziz M Elkhogia, Andrew KN Ndonga, Zipporah WW Ngumi, Akinyinka O Omigbodun, Simbo D Amanor-Boadu, Eugene Zoumenou, Apollo Basenero, Dolly M Munlemvo, Coulibaly Youssouf, Gabriel Ndayisaba, Akwasi Antwi-Kusi, Veekash Gobin, Patrice Forget, Bernard Mbwele, Henry Ndasi, Sylvia R Rakotoarison, Ahmadou L Samateh, Ryad Mehyaoui, Ushmaben Patel-Mujajati, Chaibou M Sani, Tonya M Esterhuizen, Thandinkosi E Madiba, Rupert M Pearse, Bruce M Biccard, Hippolyte Abadagan, N Abbas, A Ibrahim Abdelatif, Traoré Abdoulaye, A Abd-rouf, A Abduljalil, A Abdulrahman, S Abdurazig, A Abokris, W Abozaid, SOA Abugassa, F Abuhdema, SA Abujanah, R Abusamra, A Abushnaf, SA Abusnina, TS Abuzalout, HM Ackermann, YB Adamu, A Addanfour, DM Adeleke, TA Adigun, AO Adisa, Sèhivè Valéry Adjignon, NA Adu-Aryee, BB Afolabi, AFX Agaba, PKA Agaba, K Aghadi, H Agilla, B Ahmed, El-Z Ahmed, Al-J Ahmed, M Ahmed, Rene Ahossi, SA Aji, S Akanyun, I Akhideno, M Akhter, OA Akinyemi, M Akkari, Joseph Akodjenou, AL AL Samateh, ES al Shams, OT Alagbe-Briggs, EA Alakkari, RB Alalem, M Alashhab, OI Alatise, A Alatresh, MSI Alayeb Alayeb, BA Albakosh, F Albert, ANJD Alberts, AD Aldarrat, A Alfari, A Alfetore, M Algbali, A Algddar, HA Algedar, IA Alghafoud, A Alghazali, M Alhajj, A Alhendery Alhendery, FFH Alhoty, A Ali, YA Ali, Beye Seïdina Alioune, MA Alkassem, MA Alkchr, TS Alkesa, A Alkilani, F Alkobty Alkobty, Thomas Allaye, SBM Alleesaib, A Alli, K Allopi, NL Allorto, A Almajbery, R Almesmary, SHA Almisslati, F Almoraid, H Alobeidi, MA Alomami, Christella S Alphonsus, OA Alqawi, AA Alraheem, SA Alsabri, A Alsayed, B Alsellabi, M Al-Serksi, MSA Alshareef, AA Altagazi, JS Aluvale, HW Alwahedi, EA Alzahra, MA Alzarouk, K Al-Zubaidy, M Amadou, Maiga Amadou, Al-A Amer, BT Amisi, MA Amuthenu, TWA Anabah, Felix Anani, PGR Anderson, AGB Andriamampionona, L Andrianina, A Anele, R Angelin, N Anjar, O Antùnez, LJC Anyanwu, AA Aribi, OA Arowolo, O Arrey, Daniel Zemenfes Ashebir, SB Assefa (Elsevier, 2019-04-01)
      Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes. Methods A 7-day, international, ...

    • Explaining the slowdown in medical spending growth among the elderly, 1999-2012. 

      Salim S Virani, Alvaro Alonso, Emelia J Benjamin, Marcio S Bittencourt, Clifton W Callaway, April P Carson, Alanna M Chamberlain, Alexander R Chang, Susan Cheng, Francesca N Delling, Luc Djousse, Mitchell SV Elkind, Jane F Ferguson, Myriam Fornage, Sadiya S Khan, Brett M Kissela, Kristen L Knutson, Tak W Kwan, Daniel T Lackland, Tené T Lewis, Judith H Lichtman, Chris T Longenecker, Matthew Shane Loop, Pamela L Lutsey, Seth S Martin, Kunihiro Matsushita, Andrew E Moran, Michael E Mussolino, Amanda Marma Perak, Wayne D Rosamond, Gregory A Roth, Uchechukwu KA Sampson, Gary M Satou, Emily B Schroeder, Svati H Shah, Christina M Shay, Nicole L Spartano, Andrew Stokes, David L Tirschwell, Lisa B VanWagner, Connie W Tsao, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee, American Heart Association, National Center for Health Statistics, Centers for Disease Control and Prevention, National Center for Health Statistics, US Census Bureau population estimates: historical data: 2000s, US Census Populations With Bridged Race Categories, National Center for Health Statistics, World Health Organization, National Center for Health Statistics, RN Anderson, HM Rosenberg, DM Lloyd-Jones, Y Hong, D Labarthe, D Mozaffarian, LJ Appel, L Van Horn, K Greenlund, S Daniels, G Nichol, GF Tomaselli, American Heart Association Strategic Planning Task Force and Statistics Committee, American Heart Association, JS Rumsfeld, KP Alexander, DC Goff Jr, MM Graham, PM Ho, FA Masoudi, DK Moser, VL Roger, MS Slaughter, KG Smolderen, American Heart Association Council on Quality of Care and Outcomes Research, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, and Stroke Council, CM Shay, HS Gooding, R Murillo, R Foraker, Y Chang, X Guo, Y Chen, L Guo, Z Li, S Yu, H Yang, G Sun, Y Sun, T Laitinen, TT Laitinen, K Pahkala, CG Magnussen, M Oikonen, JS Viikari, MA Sabin, SR Daniels, OJ Heinonen, L Taittonen, O Hartiala, A Younus, EC Aneni, ES Spatz, CU Osondu, L Roberson, O Ogunmoroti, R Malik, SS Ali, M Aziz, T Feldman, L Zhou, L Zhao, Y Wu, Y Wu, X Gao, Y Li, J Mai, Z Nie, Y Ou, M Guo, HM González, W Tarraf, CJ Rodríguez, LC Gallo, RL Sacco, GA Talavera, G Heiss, JR Kizer, R Hernandez, S Davis, A Spahillari, S Talegawkar, A Correa, JJ Carr, JG Terry, J Lima, JE Freedman, S Das, R Kociol, S de Ferranti, AR Folsom, H Yatsuya, JA Nettleton, PL Lutsey, M Cushman, WD Rosamond, ARIC Study Investigators, CJ Murray, C Atkinson, K Bhalla, G Birbeck (RTI International, 202-03-03)
      The American Heart Association, in conjunction with the National Institutes of Health, annually reports on the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core ...

    • Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels 

      Okumu, Wilson; Okeyo, Winnie A; Munde, Elly O; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BioMed Central, 2013-12)
      In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...

    • (− 7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels 

      Okumu, Wilson; Okeyo, Winnie A; Munde, Elly O; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (Bio Med Central, 2013)
      In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...

    • Elly O. Munde, Winnie A. Okeyo, Samwel B. Anyona, Evans 

      Okumu, Wilson; Vulule, John; Ouma, Collins; Raballah, Stephen Konah; Ogonda, Lilian (2012)
      An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (Fc ...

    • The lipid acyl-chain dynamics in giant liposomes and characterization of domain 4 of the Wilson disease protein 

      Okumu, Wilson (2010)
      Steady-state and nanosecond time-resolved fluorescence of the nitro-2, 1, 3- benzoxadiazol-4-yl (NBD) probe and line tension force were determined in phospholipids acyl-chain dynamics in giant liposomes made from a homologous ...

    • Selective Blockade of Trypanosomatid Protein Synthesis by a Recombinant Antibody Anti-Trypanosoma cruzi P2β Protein 

      Ayub, Maximiliano J; Nyambega, Benson; Simonetti, Leandro; Duffy, Tomas; Longhi, Silvia A; Gómez, Karina A; Hoebeke, Johan; Levin, Mariano J; Smulski, Cristian R (Public Library of Science, 2012-05-03)
      The ribosomal P proteins are located on the stalk of the ribosomal large subunit and play a critical role during the elongation step of protein synthesis. The single chain recombinant antibody C5 (scFv C5) directed against ...

    • Proteins Associated with SF3a60 in T. brucei 

      Nyambega, Benson; Helbig, Claudia; Masiga, Daniel K; Clayton, Christine; Levin, Mariano J (Public Library of Science, 2014-03-20)
      Trypanosoma brucei relies on Spliced leader trans splicing to generate functional messenger RNAs. Trans splicing joins the specialized SL exon from the SL RNA to pre-mRNAs and is mediated by the trans-spliceosome, which ...

    • An investigation into factors predisposing workers to high levels of Pesticide exposure in Machakos District, Kenya 

      Momanyi, Violet N; Nyambega, Benson; Onyango, Mary A (2015-11)

    • Depletion of trypanosome CTR9 leads to gene expression defects 

      Ouna, Benard A; Nyambega, Benson; Manful, Theresa; Helbig, Claudia; Males, Matilda; Fadda, Abeer; Clayton, Christine (Public Library of Science, 2012-04-20)
      The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA ...

    • Functional characterization and protein–protein interactions of trypanosome splicing factors U2AF35, U2AF65 and SF1 

      Vazquez, Martin P; Mualem, David; Bercovich, Natalia; Stern, Michael Z; Nyambega, Benson; Barda, Omer; Masiga, Dan; Gupta, Sachin K; Michaeli, Shulamit; Levin, Mariano J (Elsevier, 2009-04-01)
      Early in the assembly of the spliceosome of eukaryotes the branch-point binding protein (BBP, also called SF1) recognizes the branch point sequence, whereas the heterodimer U2AF consisting of a 65 and a 35 kDa subunit, ...

    • Protein–protein interaction map of the Trypanosoma cruzi ribosomal P protein complex 

      Ayub, Maximiliano J; Smulski, Cristian R; Nyambega, Benson; Bercovich, Natalia; Masiga, Dan; Vazquez, Martín P; Aguilar, Carlos F; Levin, Mariano J (Elsevier, 2005-09-12)
      The large subunit of the eukaryotic ribosome possesses a long and protruding stalk formed by the ribosomal P proteins. Four out of five ribosomal P proteins of Trypanosoma cruzi, TcP0, TcP1α, TcP2α, and TcP2β had been ...

    • Molecular characterization of tsetse’s proboscis and its response to Trypanosoma congolense infection 

      Awuoche, Erick O; Weiss, Brian L; Vigneron, Aurélien; Mireji, Paul O; Aksoy, Emre; Nyambega, Benson; Attardo, Geoffrey M; Wu, Yineng; O’Neill, Michelle; Murilla, Grace; Aksoy, Serap (Public Library of Science, 2017)
      Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities ...

    • Effect of naturally occurring plant quinones on insect flight muscle mitochondrial respiration 

      Makawiti, DW; Okinji, VN; Magir, En (1997-07-31)

    • Olwa-Odyek: Enthnopharmacological screenings of Vernonia amygdalina and Cleome gynandra traditionally used in child birth in Western Uganda 

      Kamatenesi, MM; Makawiti, DW; Origa, H Oryem (2005)