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Malignant obstructive jaundice: Factors predictive of non Resectability at kenyatta National Hospital
(University of Nairobi, 2010)
Malignant obstructive jaundice is a rising cause of mortality and morbidity in surgical patients worldwide. Most patients at time of presentation have advanced disease. Surgery remains the only curative mode of treatment ...
Sigmoid volvulus in pregnancy
(The Surgical Society of Kenya, 2010)
Sigmoid volvulus in pregnancy is a rare condition that poses a myriad of challenges in diagnosis and management of the patient. It demands on the clinician a high index of suspicion, immediate treatment involving resuscitation ...
Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa
(Taylor & Francis, 2019)
A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-Saharan Africa showed RTS,S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children (enrolled ...
A comparison of all-cause and cause-specific mortality by household socioeconomic status across seven INDEPTH network health and demographic surveillance systems in sub-Saharan AfricaA comparison of all-cause and cause-specific mortality by household socioeconomic status across seven INDEPTH network health and demographic surveillance systems in sub-Saharan Africa
(Taylor & FrancisTaylor & Francis, 2019)
ABSTRACT
Background: Understanding socioeconomic disparities in all-cause and cause-specific mortality can help inform prevention and treatment strategies.
Objectives: To quantify cause-specific mortality rates by ...
Molecular identity of mycobacteria isolates in new cases of pulmonary tuberculosis patients in Kisumu County, Western Kenya
(tuberculosis, 2017)
Pulmonary tuberculosis (TB) remains one of the most challenging diseases to control in the world
today and it has become a major global health problem especially in immunocompromised people such as
HIV/AIDS. The problem ...
A Spatiotemporal Analysis of HIV-Associated Mortality in Rural Western Kenya 2011–2015
(2018)
Background: Reliable data on the HIV epidemic is critical for the
measurement of the impact of HIV response and for the implementation of further interventions.
Methods: We used mortality data from the Kombewa health ...
Genetic diversity and protective efficacy of the RTS, S/AS01 malaria vaccine
(Massachusetts Medical Society, 2015)
BACKGROUND
The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated ...
Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries
(BioMed Central, 2017)
Background
Plasmodium falciparum prevalence (PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial ...
Safety and immunogenicity of RTS, S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial
(Elsevier, 2016)
Background
Malaria remains a major global public health concern, especially in sub-Saharan Africa. The RTS,S/AS01 malaria candidate vaccine was reviewed by the European Medicines Agency and received a positive scientific ...
Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
(Elsevier, 2015)
Background The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated
with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporo ...