Macro CK in patients with elevated troponin I levels: case report: online article
Ruchika Kohli-Kochhar, Evelyne Mulwa, Geoffrey Omuse, Peter Ojwang
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CK-MB activity levels can be falsely elevated by the presence of macro CK, especially if immuno-inhibition assays are used in the measurement. In patients with macro CK and cardiac pathology that could result in an elevated CK-MB activity, the diagnostic challenge lies in determining the true cause of the elevated CK-MB activity. We present two case reports of patients with elevated CK-MB activity and troponin I levels, but who subsequently had CK-MB activity higher than total CK activity, raising the suspicion of the presence of macro CK.