Browsing Biomedical Science by Title
Now showing items 21-39 of 39
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Immunophenotypic Characterization of Lymphocyte Subsets -Expressing Programmed Death-L (Pd-L) in Individuals Exposed to Differential Malaria Transmission Patterns and Endemic Burkitt's Lymphoma
(Maseno University, 2011)Repeated..challenge'of the immune system by chronicexposure to high antigen.levels due to persistent infection may lead to development of impaired T-cells that are not effective in . . . . .' \ mediatingimmune functions. ... -
Influence of cyp2b6 polymorphisms on cd4+ t cell count and HIV RNA viral load changes among individuals on nevirapine Containing highly active antiretroviral therapy
(Maseno University, 2016)Human Immunodeficiency Virus (HIV) remains the leading cause of morbidity and mortality in Kenya with a prevalence of 6.5%. Highly active antiretroviral therapy (HAART) is used to manage the disease by increasing the CD4 ... -
Interaction between shigella flexneri and intestinal epithelial cells co-infected with selected enteric bacteria
(Maseno University, 2015)Bacteria, intestinal epithelium, and host innate immune responses are among the most critical interacting factors that determine the fate of bacterial infections and disease outcomes. Recent studies have described multiple ... -
Isoniazid and Rifampicin Resistance and Patient Treatment Response in a Tuberculosis and Hiv-1 Co-Endemic Population in Western Kenya in 2012-2014
(Maseno University, 2017)In 2015, 10.4 million people worldwide had tuberculosis (TB) and 1.4 million deaths occurred, 400 000 of whom were HIV-positive, Sub-Saharan Africa (SSA) accounted for 81% of these cases. In 2015, 480 000 new cases of ... -
Lack of Association between Interleukin-6 (-174g/C),Interleukin-Io (-1082a/G, -819c/T, And -592c/A) Polymorphisms and Susceptibility to Endemic Burkitt Lymphoma in Children Aged between 5-8 Years from Western Kenya
(Maseno University, 2013)Endemic Burkitt lymphoma (eBL) is the most common paediatric cancer in sub-Saharan Africa and occurs at a high incidence in western Kenya. The tumour has the highest proliferative rate of any other human cancer. Although ... -
Mechanisms Responsible for Insecticide Resistance in Anopheles Gambiae S.L. Populations of AHERO, BUDALANGI and BUNGOMA in Western Kenya
(Maseno University, 2011)As malaria control interventions directed against Anopheles vectors through the distribution of insecticide-treated bednets (ITNs) and application of indoor residual sprays (IRS) increase in sub-SaharanAfrica, it is crucial ... -
Molecular analysis of HIV mutations and determination Of subtypes circulating in gem, western Kenya
(Maseno university, 2010)As the HIV pandemic becomes increasingly complex and devastating in Africa, there is need to come up with better management strategies in terms of treatment, vaccine and better testing methods. However, this is getting ... -
Multiple cytokine responses to mycobacterium tuberculosis antigens in bacille calmette guerrin vaccinated children at Jaramogi Oginga Odinga teaching and referral Hospital in KIsumu county, Western Kenya.
(Maseno University, 2016)The diagnosis and control of tuberculosis (TB) has taken various dimensions with interferon Gamma (IFN-γ) Release Assays (IGRA) currently employed for diagnosis of latent TB infection while the conventional method of ... -
Phenotypic characterization of virulence, evolutionary Relationship and global expansion in Trypanosoma evansi isolates from Surra endemic regions
(Maseno University, 2018)ABSTRACT Trypanosoma evansi parasite is the causative agent of trypanosomiasis (surra) in camels and other livestock with devastating economic consequences in many parts of the world, including Kenya, Vietnam, Brazil, ... -
Plasmodium Falciparum Malaria Transmission Effects on Natural Killer Cell Function in the Etiology of Endemic Burkitt Lymphoma in Children From Western Kenya
(Maseno University, 2016)ABSTRACT The exact etiological mechanism underlying endemic Burkitt lymphoma (eBL) remains unknown. Past studies show T and B cells are immuno-deregulated in children from malaria holoendemic regions. However, no study ... -
Polymorphisms of toll like receptor 4 (-8984c/g and 299asp/gly) and Interferon gamma levels in children with severe Plasmodium Falciparum malaria Anaemia in Siaya county, Western Kenya
(Maseno University, 2018)Plasmodium falciparum (P. falciparum) malaria is a major cause of childhood morbidity and mortality in Sub-Saharan Africa despite the integrated approaches put in place to control the disease. Most of the mortality in ... -
Prevalence and intensity of the common Parasitic infections and Anaemia in street children compaired to school going children in Kisumu city, Kenya.
(Maseno University, 2018)The provision of skilled care during delivery is an indicator to monitor progress in reducing maternal mortality and falls in Goal 3 of the Sustainable Development Goals (SDGs). However, the proportion of Skilled Birth ... -
Prevalence, molecular pathotypes, clinical outcomes and antibiotic profiles of escherichia coli, salmonella and shigella from diarrhoea inpatients aged below five years at Moi Teaching and Referral Hospital
(Maseno University, 2015)Diarrhoea remains a major cause of mortality and morbidity worldwide. Diarrhoea in low income settings is attributed to bacterial enteropathogens but viruses and parasites may also be involved. Children infected with HIV ... -
Prevalence, source tracking and antimicrobial resistance of selected pathogenic bacteria in street vended foods sold in Kisumu city, Western Kenya
(Maseno University, 2015)The street food industry plays an important role in developing countries by meeting the food demand of the urban dwellers. There is an increase of food vending in Kisumu city due to poor economy and un-employment. Street ... -
Serum electrolyte changes associated with kidney and liver function markers in HIV-infected individuals attending Jaramogi Oginga Odinga teaching and referral hospital, Kisumu county, kenya
(Maseno University, 2016)Serum electrolytes disorders in HIV patients in addition to resulting from disease induced fluids losses or accumulation could be attributed to a wide range of structural defects of cellular apparatus, tissue or organs ... -
Spatial distribution and Schistosomes infection prevalence of Biomphalaria snails along Lake Victoria shoreline of Mbita - Homa-bay county-Kenya
(Maseno University, 2016)Intestinal schistosomiasis caused by Schistosoma mansoni remains a major public health problem responsible for morbidity and mortality in sub-Saharan Africa despite availability of control programs. It is estimated that ... -
Temporal and spatial trends of plasmodium falciparum multi-drug resistance protein 1 gene mutations during implementation of artemisinin combination therapies between 2008 and 2019 in Kenya
(Maseno university, 2021)Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi-drug resistance protein 1 (Pfmrp1) gene have previously been associated with conferring resistance against artemisinin and its partner drugs in ... -
Use of conventional and molecular techniques to Determine the prey alence of shigella and Enteroinv asive escherichia coli strains from Diarrhoea patients in selected health facilities in Rural western Kenya
(Maseno university, 2009)Diarrhoea is a major cause of infant morbidity and mortality worldwide. It accounts for 1.6- 2.5 million deaths annually and each child in the developing world experiences an average of three episodes of diarrhoea per ... -
Validation of Gene xpert and lam using urine from Hiv patients with clinical signs for diagnosis of Tuberculosis attending the Moi teaching and referral hospital Eldoret Kenyan
(Maseno University, 2016)Tuberculosis (TB) and HIV co-infections have a global prevalence with high morbidity and mortality and Africa is the worst hit. The HIV and AIDS has profound impact on the TB epidemic in Kenya, where up to 60% of TB patients ...