Biomedical Science
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Assessment of plasmodium species prevalence, antimalarial drug resistance genes and gametocytes in malaria infectionsbetween 2018 and 2021 in Kombewa sub-county, Kenya
(Maseno university, 2024)In Western Kenya, malaria is a major cause of morbidity and mortality with more than 70% of the population at risk.Its decline over the last 25 years indicates a shift to older children majority of who are asymptomatic. ... -
Profile of drug resistance conferring gene mutations in Mycobacterium tuberculosis among new and previously treated pulmonary tuberculosis cases from Kisumu county, Kenya
(Maseno University, 2023)Tuberculosis (TB) remains a significant public health concern in Kisumu County, Kenya, with a high burden of drug-resistant cases. Existing studies focus on epidemiological aspects, but lack comprehensive investigation ... -
Use of conventional and molecular techniques to Determine the prey alence of shigella and Enteroinv asive escherichia coli strains from Diarrhoea patients in selected health facilities in Rural western Kenya
(Maseno university, 2009)Diarrhoea is a major cause of infant morbidity and mortality worldwide. It accounts for 1.6- 2.5 million deaths annually and each child in the developing world experiences an average of three episodes of diarrhoea per ... -
Temporal and spatial trends of plasmodium falciparum multi-drug resistance protein 1 gene mutations during implementation of artemisinin combination therapies between 2008 and 2019 in Kenya
(Maseno university, 2021)Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi-drug resistance protein 1 (Pfmrp1) gene have previously been associated with conferring resistance against artemisinin and its partner drugs in ... -
Molecular analysis of HIV mutations and determination Of subtypes circulating in gem, western Kenya
(Maseno university, 2010)As the HIV pandemic becomes increasingly complex and devastating in Africa, there is need to come up with better management strategies in terms of treatment, vaccine and better testing methods. However, this is getting ... -
Mechanisms Responsible for Insecticide Resistance in Anopheles Gambiae S.L. Populations of AHERO, BUDALANGI and BUNGOMA in Western Kenya
(Maseno University, 2011)As malaria control interventions directed against Anopheles vectors through the distribution of insecticide-treated bednets (ITNs) and application of indoor residual sprays (IRS) increase in sub-SaharanAfrica, it is crucial ... -
Immunophenotypic Characterization of Lymphocyte Subsets -Expressing Programmed Death-L (Pd-L) in Individuals Exposed to Differential Malaria Transmission Patterns and Endemic Burkitt's Lymphoma
(Maseno University, 2011)Repeated..challenge'of the immune system by chronicexposure to high antigen.levels due to persistent infection may lead to development of impaired T-cells that are not effective in . . . . .' \ mediatingimmune functions. ... -
Evaluation of the Repellency Effectiveness of Linalool and Metofluthrin against Anopheles Gambiae S.L. in Kisian Village, Western Kenya
(Maseno University, 2012)Malaria continues to pose a major public health threat. Despite the efforts that have been made to prevent humans from mosquito bites, changes in the vector biting behavior, and mosquitoes tending to bite earlier before ... -
Lack of Association between Interleukin-6 (-174g/C),Interleukin-Io (-1082a/G, -819c/T, And -592c/A) Polymorphisms and Susceptibility to Endemic Burkitt Lymphoma in Children Aged between 5-8 Years from Western Kenya
(Maseno University, 2013)Endemic Burkitt lymphoma (eBL) is the most common paediatric cancer in sub-Saharan Africa and occurs at a high incidence in western Kenya. The tumour has the highest proliferative rate of any other human cancer. Although ... -
Associations between Functional Variations in Fc'yriiia and TLR 9 and Susceptibility to Severe Malaria Anemia in Cidldren below 3 Years in Western Kenya
(Maseno University, 2013)Plasmodium Jalciparum malaria in holoendemic transmission areas is a major cause of childhood morbidity and mortality. The greatest burden of this morbidity and mortality is as a consequence of severe malaria anemia (SMA) ... -
Plasmodium Falciparum Malaria Transmission Effects on Natural Killer Cell Function in the Etiology of Endemic Burkitt Lymphoma in Children From Western Kenya
(Maseno University, 2016)ABSTRACT The exact etiological mechanism underlying endemic Burkitt lymphoma (eBL) remains unknown. Past studies show T and B cells are immuno-deregulated in children from malaria holoendemic regions. However, no study ... -
Antimicrobial Activities of Secondary Metabolites From Vernonia Adoensis and Ocimum Kilimandscharicum Medicinal Plants and Associated Endophytes From Kakamega Forest in Kenya
(Maseno University, 2016)Medicinal plants have been used for the treatment of different ailments in human and animal health systems for many years. Approximately over 80% of rural and urban African populations use plant-based synthetic products ... -
Influence of cyp2b6 polymorphisms on cd4+ t cell count and HIV RNA viral load changes among individuals on nevirapine Containing highly active antiretroviral therapy
(Maseno University, 2016)Human Immunodeficiency Virus (HIV) remains the leading cause of morbidity and mortality in Kenya with a prevalence of 6.5%. Highly active antiretroviral therapy (HAART) is used to manage the disease by increasing the CD4 ... -
Multiple cytokine responses to mycobacterium tuberculosis antigens in bacille calmette guerrin vaccinated children at Jaramogi Oginga Odinga teaching and referral Hospital in KIsumu county, Western Kenya.
(Maseno University, 2016)The diagnosis and control of tuberculosis (TB) has taken various dimensions with interferon Gamma (IFN-γ) Release Assays (IGRA) currently employed for diagnosis of latent TB infection while the conventional method of ... -
Comparison of perfomance and factors that affect circulating cathodic antigen, kato-katz and elisa tests for schistosoma mansoni diagnosis in school children in Western Kenya
(Maseno University, 2015)Schistosomiasis infects approximately 207 million people worldwide with 90% of the cases occurring in Africa. Kato-Katz, is the standard method of S.mansoni diagnosis, however it is characterized by low sensitivity. Another ... -
Comparison of hepatitis B virus sero-markers, clinical stages and genotypes between HIV-1 infected and uninfected injecting substance users in Mombasa city, Kenya
(Maseno University, 2015)Globally, it is estimated that 1.2 million injecting substance users are HBV infected while 1.7 million live with HIV. Africa is home to about 1.02 million injecting substance users of whom 12.7% are HBV infected while ... -
Comparison of diagnostic performance of mini-flotac with formalin-ether concentration and kato-katz for detection of intestinal helminths and protozoa in nursery school children in Mbita, Western Kenya
(Maseno University, 2016)Schistosoma mansoni (S. mansoni), soil-transmitted helminths (STH) and protozoa affect approximately 2 billion people world-wide. Most of these infections occur in developing countries and children below 14 years of age ... -
Prevalence, source tracking and antimicrobial resistance of selected pathogenic bacteria in street vended foods sold in Kisumu city, Western Kenya
(Maseno University, 2015)The street food industry plays an important role in developing countries by meeting the food demand of the urban dwellers. There is an increase of food vending in Kisumu city due to poor economy and un-employment. Street ... -
The diagnostic accuracy, sensitivity and specificity of fine needle aspiration cytology in evaluating thyroid masses at Moi teaching and referral hospital
(2016)Thyroid masses are common surgical presentations with a worldwide prevalence of 4–7% in the general adult population. Africa, specifically Kenya is not excluded from these surgical conditions. The vast majority of adult ... -
Characterization and source tracking of diarrheagenic bacteria contaminating fish in lake victoria, Kenya
(Maseno University, 2016)Lake Victoria is an important source of fish. Nonetheless, fish has been reported to be of low microbiological quality as they have been reported to be contaminated with Escherichia coli, Vibrio spp, Shigella spp and ...
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