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    Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia

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    Publication Date
    2023-09-13
    Author
    Onyango, Clinton O
    Cheng, Qiuying
    Munde, Elly O
    Raballah, Evans
    Anyona, Samuel B
    McMahon, Benjamin H
    Lambert, Christophe G
    Onyango, Patrick O
    Schneider, Kristan A
    Perkins, Douglas J
    Ouma, Collins
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    Abstract/Overview
    Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common clinical manifestation of severe malaria in such regions. Although innate immune response genes are known to influence the development of SMA, the role of natural killer (NK) cells in malaria pathogenesis remains largely undefined. As such, we examined the impact of genetic variation in the gene encoding a primary NK cell receptor, natural cytotoxicity-triggering receptor 3 (NCR3), on the occurrence of malaria and SMA episodes over time.
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    https://repository.maseno.ac.ke/handle/123456789/5783
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