Browsing Department of Medical Biochemistry by Author "Nyambega, Benson"
Now showing items 1-7 of 7
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Depletion of trypanosome CTR9 leads to gene expression defects
Ouna, Benard A; Nyambega, Benson; Manful, Theresa; Helbig, Claudia; Males, Matilda; Fadda, Abeer; Clayton, Christine (Public Library of Science, 2012-04-20)The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA ... -
Functional characterization and protein–protein interactions of trypanosome splicing factors U2AF35, U2AF65 and SF1
Vazquez, Martin P; Mualem, David; Bercovich, Natalia; Stern, Michael Z; Nyambega, Benson; Barda, Omer; Masiga, Dan; Gupta, Sachin K; Michaeli, Shulamit; Levin, Mariano J (Elsevier, 2009-04-01)Early in the assembly of the spliceosome of eukaryotes the branch-point binding protein (BBP, also called SF1) recognizes the branch point sequence, whereas the heterodimer U2AF consisting of a 65 and a 35 kDa subunit, ... -
An investigation into factors predisposing workers to high levels of Pesticide exposure in Machakos District, Kenya
Momanyi, Violet N; Nyambega, Benson; Onyango, Mary A (2015-11) -
Molecular characterization of tsetse’s proboscis and its response to Trypanosoma congolense infection
Awuoche, Erick O; Weiss, Brian L; Vigneron, Aurélien; Mireji, Paul O; Aksoy, Emre; Nyambega, Benson; Attardo, Geoffrey M; Wu, Yineng; O’Neill, Michelle; Murilla, Grace; Aksoy, Serap (Public Library of Science, 2017)Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities ... -
Proteins Associated with SF3a60 in T. brucei
Nyambega, Benson; Helbig, Claudia; Masiga, Daniel K; Clayton, Christine; Levin, Mariano J (Public Library of Science, 2014-03-20)Trypanosoma brucei relies on Spliced leader trans splicing to generate functional messenger RNAs. Trans splicing joins the specialized SL exon from the SL RNA to pre-mRNAs and is mediated by the trans-spliceosome, which ... -
Protein–protein interaction map of the Trypanosoma cruzi ribosomal P protein complex
Ayub, Maximiliano J; Smulski, Cristian R; Nyambega, Benson; Bercovich, Natalia; Masiga, Dan; Vazquez, Martín P; Aguilar, Carlos F; Levin, Mariano J (Elsevier, 2005-09-12)The large subunit of the eukaryotic ribosome possesses a long and protruding stalk formed by the ribosomal P proteins. Four out of five ribosomal P proteins of Trypanosoma cruzi, TcP0, TcP1α, TcP2α, and TcP2β had been ... -
Selective Blockade of Trypanosomatid Protein Synthesis by a Recombinant Antibody Anti-Trypanosoma cruzi P2β Protein
Ayub, Maximiliano J; Nyambega, Benson; Simonetti, Leandro; Duffy, Tomas; Longhi, Silvia A; Gómez, Karina A; Hoebeke, Johan; Levin, Mariano J; Smulski, Cristian R (Public Library of Science, 2012-05-03)The ribosomal P proteins are located on the stalk of the ribosomal large subunit and play a critical role during the elongation step of protein synthesis. The single chain recombinant antibody C5 (scFv C5) directed against ...