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Synergism in Antiplasmodial Activities of Artemether and Lumefantrine in Combination with Securidaca longipedunculata Fresen (Polygalaceae)
(MDPI, 2021)
Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden. Since the deployment of artemisinin-based ...
Effects of Achyranthes aspera, Bidens pilosa and Ajuga remota Leaf extracts on the blood glucose levels and hemoparameters in male goats treated with Alloxan
(AJOL, 2021)
Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus the disease constitutes a major health concern. Presently, it is an incurable metabolic disorder which affects about 2.8% of the global ...
Immunohistochemical Analysis of Prostein Expression in Archived Prostatic Core Biopsies from Prostate Cancer Patients in Western Kenya
(Research Square, 2021)
Prostate cancer is the leading cause of cancer-associated mortality in men. Most of the current
biomarkers for detection of the disease have low sensitivity and specificity. Prostein is a newly reported
prostate cancer ...
Determinants of tuberculosis treatment interruption among patients in Vihiga County, Kenya
(PLOS ONE, 2021)
Despite robust Tuberculosis (TB) program with effective chemotherapy and high coverage,
treatment interruption remains a serious problem. Interrupting TB treatment means that
patients remain infectious for longer time ...
Incidence of Brucella infection in various livestock species raised under the pastoral production system in Isiolo County, Kenya
(Springer, 2021)
We implemented a longitudinal study to determine the incidence of Brucella infection in cattle, camels, sheep and goats that were being raised in a pastoral area in Isiolo County, Kenya. An initial cross-sectional survey ...
Low sensitivity of the careHPV™ Assay for detection of Oncogenic Human Papillomavirus in cervical samples from HIV-infected and HIV-uninfected Kenyan women
(HSPC, 2020)
Human papillomavirus (HPV) infection causes cervical cancer (CC), a common
malignancy among Kenyan women. New CC screening methods rely on oncogenic HPV (“highrisk”, or HR-HPV) detection, but most have not been evaluated ...
The diagnostic accuracy of Th1 (IFN-γ, TNF-α, and IL-2) and Th2 (IL-4, IL-6 and IL-10) cytokines response in AFB microscopy smear negative PTB- HIV co-infected patients
(Springer, 2019)
Acid Fast Bacilli (AFB) microscopy smear remains the most widely used laboratory diagnostic technique
for Pulmonary Tuberculosis (PTB) in low-and-middle income countries. Although it is highly specifc,
the sensitivity ...
Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling
(science direct, 2019)
Leukocyte-associated immunoglobulin like receptor-1 (LAIR1) is a transmembrane inhibitory receptor that influences susceptibility to a myriad of inflammatory diseases. Our recent investigations of severe malarial anaemia ...
Sero-Prevalence and Molecular Analysis of Brucellosis in Livestock Keepers and Domestic Ruminants in Baringo County, Kenya
(Research square, 2022)
Brucellosis is widely distributed in more than 170 countries around the world, where it poses
a huge threat to animal husbandry and human health. Brucellosis is a worldwide re-emerging zoonotic
disease that poses serious ...
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
(BioMed Central, 2022)
Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte ...