Browsing Department of Biomedical Sciences by Title
Now showing items 30-49 of 81
-
Evaluating Antiplasmodial and Antimalarial Activities of Soybean (Glycine max) Seed Extracts on P. falciparum Parasite Cultures and P. berghei-Infected Mice
(Hindawi, 2020-02-17)Plasmodium parasite resistance to artemisinin-based combination therapies (ACTs) calls for development of new, affordable, safe, and effective antimalarial drugs. Studies conducted previously on soybean extracts have ... -
Evaluation of cercaricidal and miracicidal activity of selected plant extracts agains larval stages of Schistosoma mansoni
(Journal of Natural Sciences Research, 2016)Schistosomiasis is a parasitic disease caused by blood-flukes of the genus Schistosoma. It is one of the most widespread of all human parasitic diseases, ranking second only to malaria in terms of its socioeconomic and ... -
Evidence of co-exposure with Brucella spp, Coxiella burnetii, and Rift Valley fever virus among various species of wildlife in Kenya
(Public Library of Science, 2022-09)Co-infection, especially with pathogens of dissimilar genetic makeup, may result in a more devastating impact on the host. Investigations on co-infection with neglected zoonotic pathogens in wildlife are necessary to ... -
Factors influencing patients’ adherence to malaria Artemisinin-based combination therapy treatment in Kamuli District, Uganda
(Research Square, 2023-10-06)Patients’ adherence to prescribed Artemisinin-based Combination Therapy (ACT) treatment is a key malaria control strategy. To accelerate and realize a malaria free country, malaria management measures remain a key public ... -
Genetic differentiation in East African ethnicities and its relationship with endurance running success
(Public Library of Science, 2022)Since the 1960s, East African athletes, mainly from Kenya and Ethiopia, have dominated long-distance running events in both the male and female categories. Further demographic studies have shown that two ethnic groups are ... -
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
(BioMed Central, 2022)Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte ... -
Growth characteristics and production of secondary metabolites from selected novel Streptomyces species isolated from selected Kenyan national parks
(JKUAT ANNUAL SCIENTIFIC CONFERENCE PROCEEDINGS, 2010)The aim of study was to characterize growth of novel Streptomyces isolates as well as the secondary metabolites they were producing. Four Streptomyces isolates from Chyulu National Park (Chy 4 -10, Chy 15-10, Chy 15-5 and ... -
Habitat selection and vertical inheritance drive archaeal community structure in arthropod guts
(ECOLOGICAL AND EVOLUTIONARY DRIVERS OF MICROBIAL COMMUNITY STRUCTURE IN TERMITE GUTS, 2015)The arthropod gut is streamlined to anaerobically mineralize mostly plant-derived organic matter. In only five major arthropod groups (millipedes, scarab beetle larvae, cockroaches, and lower and higher termites) are ... -
Health Providers’ Self Reported Provision of Preconception Care and Associated Factors in Kisumu County-kenya
(Research square, 2023-09-01)Preconception care (PCC) is the provision of health interventions to women and couples before conception occurs and is valuable in preventing and controlling noncommunicable diseases. In Africa, more so in Kenya, maternal ... -
Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya
(BioMed Central, 2023)Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. P. falciparum ... -
Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia
(BioMed Central, 2023-09-13)Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common clinical ... -
Immunohistochemical Analysis of Prostein Expression in Archived Prostatic Core Biopsies from Prostate Cancer Patients in Western Kenya
(Research Square, 2021)Prostate cancer is the leading cause of cancer-associated mortality in men. Most of the current biomarkers for detection of the disease have low sensitivity and specificity. Prostein is a newly reported prostate cancer ... -
Impact of Four Years of Annual Mass Drug Administration on Prevalence and Intensity of Schistosomiasis among Primary and High School Children in Western Kenya: A Repeated Cross-Sectional Study.
(The American journal of tropical medicine and hygiene, 2018-03-12)Schistosomiasis remains a major public health problem in Kenya. The World Health Organization recommends preventive chemotherapy with praziquantel (PZQ) to control morbidity due to schistosomiasis. Morbidity is considered ... -
Impact of integrated water, sanitation, hygiene, health and nutritional interventions on diarrhoea disease epidemiology and microbial quality of water in a resource-constrained setting in Kenya: A controlled intervention study
(Wiley online library, 2022)We assessed the impact of water, hygiene and sanitation (WASH), maternal,new-born and child health (MNCH), nutrition and early childhood development (ECD) on diarrhoea and microbial quality of water in a resource-constrained ... -
Impact of processing methods on microbial load of reared and wild-caught edible crickets (Scapsipedus icipe and Gryllus bimaculatus) in Kenya
(Wageningen Academic Publishers, 2019-07-10)The microbial composition of farmed and wild Scapsipedus icipe and Gryllus bimaculatus is presented. The aim of this study is to determine the microbial load of the two cricket species and evaluate the efficiency of ... -
Incidence of Brucella infection in various livestock species raised under the pastoral production system in Isiolo County, Kenya
(Springer, 2021)We implemented a longitudinal study to determine the incidence of Brucella infection in cattle, camels, sheep and goats that were being raised in a pastoral area in Isiolo County, Kenya. An initial cross-sectional survey ... -
Influence of landscape heterogeneity on entomological and parasitological indices of malaria in Kisumu, Western Kenya
(BioMed Central, 2022)Identification and characterization of larval habitats, documentation of Anopheles spp. composition and abundance, and Plasmodium spp. infection burden are critical components of integrated vector management. The present ... -
Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
(Biochemistry and Biophysics Reports, 2022)Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the malarial parasite product, hemozoin (PfHz), by circulating phagocytic ... -
Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
(Springer, 2017)Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of ... -
Investigating treatment response of patients with confirmed drug-resistant tuberculosis in an hiv-1-endemic population in western Kenya
(BMJ, 2019)In 2015, 10.4 million people worldwide had tuberculosis (TB) and 1.4 million deaths occurred, 400 000 of whom were HIV-positive. Sub-Saharan Africa accounted for 81% of these cases. In western Kenya, current data on the ...