Browsing Internal Medicine by Title
Now showing items 17-36 of 57
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Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L …
(Royal Society of Tropical Medicine and Hygiene, 2008)Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured ... -
Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?
(The American Society of Tropical Medicine and Hygiene, 2008)We assessed the effect of daily cotrimoxazole, essential for HIV care, on development of antifolateresistant Plasmodium falciparum, naso-pharyngeal Streptococcus pneumoniae (pneumococcus), and commensal Escherichia coli. ... -
The effect of health care worker training on the use of intermittent preventive treatment for malaria in pregnancy in rural western Kenya
(Blackwell Publishing Ltd, 2007)background In 1998, Kenya adopted intermittent preventive treatment (IPTp) with sulphadoxinepyrimethamine (SP) for malaria prevention during pregnancy. We conducted a survey in 2002 among women who had recently delivered ... -
Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial
(The American Society of Tropical Medicine and Hygiene, 2009)Shortly after Kenya introduced artemether-lumefantrine (AL) for first-line treatment of uncomplicated malaria, we conducted a pre-post cluster randomized controlled trial to assess the effect of providing malaria rapid ... -
Effectiveness of Antenatal Clinics to Deliver Intermittent Preventive Treatment and Insecticide
(2013)Background: Malaria in pregnancy can have devastating consequences for mother and baby. Coverage with the WHO prevention strategy for sub-Saharan Africa of intermittent-preventive-treatment (IPTp) with two doses of ... -
Effectiveness of antenatal clinics to deliver intermittent preventive treatment and insecticide treated nets for the control of malaria in pregnancy in Kenya
(Public Library of Science, 2013)Background: Malaria in pregnancy can have devastating consequences for mother and baby. Coverage with the WHO prevention strategy for sub-Saharan Africa of intermittent-preventive-treatment (IPTp) with two doses of ... -
Effectiveness of the delivery of interventions to prevent malaria in pregnancy in Kenya
(BioMed Central, 2016)Background Coverage with malaria in pregnancy interventions remains unacceptably low. Implementation research is needed to identify and quantify the bottlenecks for the delivery and use of these life-saving interventions ... -
Epidemiology of Microbial Keratitis in Uganda: A Cohort Study
(Taylor & Francis, 2020)Purpose: To describe the epidemiology of Microbial Keratitis (MK) in Uganda. Methods: We prospectively recruited patients presenting with MK at two main eye units in Southern Uganda between December 2016 and March 2018. ... -
A Fatal Case of Infant Oral Mutilation Practice
(University of Nairobi, 2021)Infant oral mutilation (IOM) is a traditional dental practice where traditional healers enucleate primary canine tooth buds in children in the hope of preventing or curing childhood illness. The method applied is ... -
Haemostatic disorders in patients with breast cancer at Kenyatta national hospital, Kenya
(University of Nairobi, 2010)Haemostatic disorders (thrombosis and haemorrhage) are increasingly being investigated and assessed as factors that influence outcome of treatment of solid tumors including breast cancer. There is little data available ... -
The impact of microbial keratitis on quality of life in Uganda
(BMJ Specialist Journals, 2019)Background Microbial keratitis (MK) is a frequent cause of sight loss in sub-Saharan Africa. However, no studies have formally measured its impact on quality of life (QoL) in this context. Methods As part of a nested ... -
Influence of changing day secondary into boarding on students’ participation in public secondary schools in Trans Nzoia West, Kenya
(University of Nairobi, 2015)Changing day secondary into boarding schools is an emerging trend in education sector in Kenya. This trend however tends to affect students’ participation in education. This study was conducted in schools that changed from ... -
Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV
(2014)Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women ... -
Intermittent preventive treatment of malaria in pregnancy with mefloquine in HIV-infected women receiving cotrimoxazole prophylaxis: a multicenter randomized placebo-controlled
(Public Library of Science, 2014)Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women ... -
Intermittent Screening and Treatment or Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine Versus Intermittent Preventive Treatment With Sulfadoxine …
(LWW, 2016)In sub-Saharan Africa, there are >32 million pregnancies annually. As this is a malaria-endemic region, it is estimated approximately 12 million women who have live births (45% of live births) would be exposed to malaria ... -
Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin–piperaquine versus intermittent preventive treatment with sulfadoxine …
(Elsevier, 2015)Background Every year, more than 32 million pregnancies in sub-Saharan Africa are at risk of malaria infection and its adverse consequences. The effectiveness of the intermittent preventive treatment with sulfadoxine–py ... -
Intermittent screening and treatment with dihydroartemisinin-piperaquine for the prevention of malaria in pregnancy: implementation feasibility in a routine healthcare system …
(BioMed Central, 2020): Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for preventing malaria in pregnancy in areas of moderate-to-high transmission in sub-Saharan Africa. However, due ... -
Kaposi's sarcoma-associated herpesvirus protein ORF75 among HIV-1 patients in Kenya
(AOSIS Publishing, 2020)Histology is used to identify Kaposi's sarcoma (KS) in countries with low resources to fund healthcare costs. Approximately 95% of KS cases can be detected using a polymerase chain reaction -
Knowledge and adherence to the national guidelines for malaria case management in pregnancy among healthcare providers and drug outlet dispensers in rural, western Kenya
(Public Library of Science, 2016)Background Although prompt, effective treatment is a cornerstone of malaria control, information on provider adherence to malaria in pregnancy (MIP) treatment guidelines is limited. Incorrect or sub-optimal treatment can ... -
Knowledge and adherence to the national guidelines for malaria diagnosis in pregnancy among health-care providers and drug-outlet dispensers in rural Western Kenya
(The American Society of Tropical Medicine and Hygiene, 2018)Prompt diagnosis and effective treatment of acute malaria in pregnancy (MiP) is important for the mother and fetus; data on health-care provider adherence to diagnostic guidelines in pregnancy are limited. From September ...