School of Medicine: Recent submissions
Now showing items 81-100 of 553
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Profiles of Isoniazid and Rifampicin drug resistance conferring mutations in Mycobacterium tuberculosis among new and previously treated pulmonary tuberculosis cases from Kisumu County, Kenya
(East African Journal of Science, Technology and Innovation, 2022)Mycobacterium tuberculosis infection is one of the leading causes of mortality and morbidity in developing countries and drug resistance remains a challenge. Drug resistance is hastened by point mutations in the bacilli ... -
Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials
(PLOS MEDICINE, 2022)Malaria is among the top causes of death in adolescent girls (10 to 19 years) globally. Adolescent motherhood is associated with increased risk of adverse maternal and neonatal outcomes. The interaction of malaria, ... -
Adverse effects of Lugol’s iodine: Heart failure in a patient with subcutaneous phycomycosis from a resource-limited setting
(Elsevier, 2022-09-09)Subcutaneous phycomycosis becomes a chronic, debilitating condition if left untreated. Treatment includes oral antifungal therapy, though oral potassium iodide has been used in resource-limited settings. Lugol's iodine has ... -
Isoniazid and Rifampicin Tuberculosis Drug Resistance in HIV Endemic Region of Western Kenya
(East Africa Science, 2022-03)Tuberculosis drug resistance is often associated with inadequate anti-tuberculosis treatment regimen resulting to mutations that confers resistance to anti-tuberculosis agents. This is aggravated by synergetic relationship ... -
Assessing the safety, impact and effectiveness of RTS,S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and study set-up
(BioMed Central, 2022)Following a 30-year development process, RTS,S/AS01E (GSK, Belgium) is the first malaria vaccine to reach Phase IV assessments. The World Health Organization-commissioned Malaria Vaccine Implementation Programme (MVIP) is ... -
Safety profile of the RTS, S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa
(Taylor & Francis, 2019-10-03)A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-Saharan Africa showed RTS, S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children ... -
Estimating Annual Fluctuations in Malaria Transmission Intensity and in the Use of Malaria Control Interventions in Five Sub-Saharan African Countries
(The American Society of Tropical Medicine and Hygiene, 2020)RTS,S/AS01E malaria vaccine safety, effectiveness, and impact will be assessed in pre- and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinate ... -
Safety and immunogenicity of the RTS, S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa
(Elsevier, 2020-01-22)We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African ... -
Estimating annual fluctuations in malaria transmission intensity and in the use of malaria control interventions in five sub-Saharan African countries
(The American Society of Tropical Medicine and Hygiene, 2020-11)RTS, S/AS01 E malaria vaccine safety, effectiveness, and impact will be assessed in pre-and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinated ... -
Immunophenotypic Characterization of ART-naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya
(Journal of Clinical Immunology and Research, 2020-11-12)Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function ... -
Case Report: An unusual case of bee envenomation presenting with acute kidney injury, cavernous venous thrombosis and multiple episodes of convulsions
(Peertechz, 2020-11-07)Bee stings are common in the tropics and cause minor problems but may occasionally cause severe anaphylactoid reactions. Summary of clinical case: We present a case of M.O.O., an 8-year-old boy who was stung three times ... -
Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya
(BioMed Central, 2020-12)Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P. falciparum endemic regions such as western ... -
Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya
(Public Library of Science, 2021-01-14)Objective To describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria. Study design In a network of seven secondary and tertiary level ... -
Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia
(Peertechz, 2021-01-19)Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly and adequately treated. In 2018 WHO put the incidence of P. falciparum Malaria in the African region ... -
Clinical laboratory hematology reference values among infants aged 1month to 17 months in Kombewa Sub-County, Kisumu: A cross sectional study of rural population in Western Kenya
(Public Library of Science, 2021-03-17)There is an urgent need for reliable region-specific hematological reference values for clinical monitoring. Laboratory reference ranges are important for assessing study participant eligibility, toxicity grading and ... -
Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS, S/AS01E …
(BioMed Central, 2021-04-26)The lack of background disease incidence rates in sub-Saharan countries where the RTS,S/AS01E malaria vaccine is being implemented may hamper the assessment of vaccine safety and effectiveness. This study aimed to document ... -
Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya
(BioMed Central, 2021-12)In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for these ... -
Caffeine for the care of preterm infants in sub-Saharan Africa: a missed opportunity?
(BMJ Specialist Journals, 2021-12-01)In 2019, 2.4 million neonates (infants< 28 days of age) died globally. Of these, over 80% were preterm infants (< 37 weeks gestation), with the majority born in low-income and middle-income countries. 1 Complications of ... -
Enteral Feeding Practices for Very Preterm and Very Low Birth Weight Infants in Nigeria and Kenya
(Frontiers in pediatrics, 2022-05-11)Optimizing nutrition in very preterm (28–32 weeks gestation) and very low birth weight (VLBW; 1,000 g to< 1,500 g) infants has potential to improve their survival, growth, and long-term health outcomes. Aim To assess ... -
Assessing the safety, impact and effectiveness of RTS, S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and …
(BioMed Central, 2022-12)Following a 30-year development process, RTS,S/AS01E (GSK, Belgium) is the frst malaria vaccine to reach Phase IV assessments. The World Health Organization-commissioned Malaria Vaccine Implementation Pro‑ gramme (MVIP) ...