School of Medicine: Recent submissions

Now showing items 101-120 of 553

    • Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases 

      M Taariq Salie, Jing Yang, Carlos R Ramírez Medina, Liesl J Zühlke, Chishala Chishala, Mpiko Ntsekhe, Bernard Gitura, Stephen Ogendo, Emmy Okello, Peter Lwabi, John Musuku, Agnes Mtaja, Christopher Hugo-Hamman, Ahmed El-Sayed, Albertino Damasceno, Ana Mocumbi, Fidelia Bode-Thomas, Christopher Yilgwan, Ganiyu A Amusa, Esin Nkereuwem, Gasnat Shaboodien, Rachael Da Silva, Dave Chi Hoo Lee, Simon Frain, Nophar Geifman, Anthony D Whetton, Bernard Keavney, Mark E Engel (BioMed Central, 2022)
      Background Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug ...

    • Linking private health sector to public COVID-19 response in Kisumu, Kenya: Lessons Learnt 

      Mevis Omollo, Isdorah A Odero, HC Barsosio, Simon Karuki, F Ter Kuile, SO Okello, K Oyoo, AK K'Oloo, K Otieno, SV Duijn, N Houben, E Milimo, R Aroka, SN Onsongo, TF Rinke de Wit (Cold Spring Harbor Laboratory Press, 2022)
      COVID-19 is overwhelming health systems universally. Increased capacity to combat the epidemic is important, while continuing regular healthcare services. This paper describes an innovative Public Private Partnership (PPP) ...

    • Efficacy of Thermal Ablation for Treatment of High-Grade Cervical Dysplasia Among HIV-Positive Women: Preliminary Results From Western Kenya 

      Chemtai Mungo, Cyrillus Ogollah, Jennifer Ambaka, Jackton Omoto, Craig Cohen (Wolters Kluwer Health, 2022)
      In 2019, the World Health Organization (WHO) endorsed thermal ablation (TA) for use within “screen-and-treat” cervical cancer prevention programs in low- and middle-income countries (LMICs), including among women living ...

    • Validation of Chloe SED, a Low-Cost, Reusable Syringe Extension Device for the Provision of Paracervical Analgesia [A21] 

      Aparna Ramanathan, Stephen Gwer, Javan L Imbamba, Stella Odenyo, Jackton Omoto, Robert C Bailey (LWW, 2022)
      Women in Kenya and other low- and middle-income countries often do not receive analgesia during manual vacuum aspiration (MVA). This pilot study evaluated the efficacy of a novel, ultra-low-cost syringe extension device ...

    • A Comprehensive COVID-19 Daily News and Medical Literature Briefing to Inform Health Care and Policy in New Mexico: Implementation Study 

      LynnMarie Jarratt, Jenny Situ, Rachel D King, Estefania Montanez Ramos, Hannah Groves, Ryen Ormesher, Melissa Cossé, Alyse Raboff, Avanika Mahajan, Jennifer Thompson, Randy F Ko, Samantha Paltrow-Krulwich, Allison Price, Ariel May-Ling Hurwitz, Timothy CampBell, Lauren T Epler, Fiona Nguyen, Emma Wolinsky, Morgan Edwards-Fligner, Jolene Lobo, Danielle Rivera, Jens Langsjoen, Lori Sloane, Ingrid Hendrix, Elly O Munde, Clinton O Onyango, Perez K Olewe, Samuel B Anyona, Alexandra V Yingling, Nicolas R Lauve, Praveen Kumar, Shawn Stoicu, Anastasiya Nestsiarovich, Cristian G Bologa, Tudor I Oprea, Kristine Tollestrup, Orrin B Myers, Mari Anixter, Douglas J Perkins, Christophe Gerard Lambert (JMIR Publications Inc., Toronto, Canada, 2022)
      Background: On March 11, 2020, the New Mexico Governor declared a public health emergency in response to the COVID-19 pandemic. The New Mexico medical advisory team contacted University of New Mexico (UNM) faculty to form ...

    • Design of a novel online, modular, flipped-classroom surgical curriculum for East, Central, and Southern Africa 

      Andrea S Parker, Katherine A Hill, Bruce C Steffes, Deirdre Mangaoang, Eric O’Flynn, Niraj Bachheta, Maria F Bates, Caesar Bitta, Nicholas H Carter, Richard E Davis, Jeremy A Dressler, Deborah A Eisenhut, Akinniyi E Fadipe, John K Kanyi, Rondi M Kauffmann, Frances Kazal, Patrick Kyamanywa, Justus O Lando, Heath R Many, Valentine C Mbithi, Amanda J McCoy, Peter C Meade, Wairimu YB Ndegwa, Emmy A Nkusi, Philip B Ooko, Dixon JS Osilli, Madison ED Parker, Sinkeet Rankeeti, Katherine Shafer, James D Smith, David Snyder, Kimutai R Sylvester, Michelle E Wakeley, Marvin K Wekesa, Laura Torbeck, Russell E White, Abebe Bekele, Robert K Parker (LWW, 2022)
      Objective: We describe a structured approach to developing a standardized curriculum for surgical trainees in East, Central, and Southern Africa (ECSA). Summary Background Data: Surgical education is essential to ...

    • Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases 

      M Taariq Salie, Jing Yang, Carlos R Ramírez Medina, Liesl J Zühlke, Chishala Chishala, Mpiko Ntsekhe, Bernard Gitura, Stephen Ogendo, Emmy Okello, Peter Lwabi, John Musuku, Agnes Mtaja, Christopher Hugo-Hamman, Ahmed El-Sayed, Albertino Damasceno, Ana Mocumbi, Fidelia Bode-Thomas, Christopher Yilgwan, Ganiyu A Amusa, Esin Nkereuwem, Gasnat Shaboodien, Rachael Da Silva, Dave Chi Hoo Lee, Simon Frain, Nophar Geifman, Anthony D Whetton, Bernard Keavney, Mark E Engel (BioMed Central, 2022)
      Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug repurposing, ...

    • Explanatory models, illness, and treatment experiences of patients with psychosis using the services of traditional and faith healers in three African countries: Similarities … 

      Olatunde Olayinka Ayinde, Olawoye Fadahunsi, Lola Kola, Lucas O Malla, Solomon Nyame, Roselyne A Okoth, Alex Cohen, John Appiah-Poku, Caleb J Othieno, Soraya Seedat, Oye Gureje (SAGE Publications, 2021)
      As part of formative studies to design a program of collaborative care for persons with psychosis, we explored personal experience and lay attributions of illness as well as treatment among persons who had recently received ...

    • Modifying Group Interpersonal Psychotherapy for Peripartum Adolescents in Sub-Saharan African Context: Reviewing Differential Contextual and Implementation Considerations 

      Manasi Kumar, Helen Verdeli, Shekhar Saxena, Inge Petersen, Keng Yen Huang, Caleb Othieno, Nancy Grote, Roslyn Law, Jurgen Unutzer, Mary McKay (SAGE Publications, 2022)
      This study describes adaptation and modification of World Health Organization (WHO) recommended group interpersonal psychotherapy (IPT-G) for depressed peripartum adolescents. The adaptation process includes accommodating ...

    • Proteotyping as alternate typing method to diferentiate Campylobacter coli clades 

      Emele MF, Možina SS, Lugert R, Bohne W, Masanta WO, Riedel T, Groß U, Bader O, Zautner AE (2019)
      Besides Campylobacter jejuni, Campylobacter coli is the most common bacterial cause of gastroenteritis worldwide. C. coli is subdivided into three clades, which are associated with sample source. Clade 1 isolates are ...

    • COVID-19’s threat to the progress in the fight against female genital mutilation in Africa 

      Shuaibu Saidu Musa, Emery Manirambona,Goodness Ogeyi Odey,Dawa Gyeltshen,Amusile Olayemi ,Ouma Atieno Sarah ,Don Eliseo Lucero- PrisnoIII (Elsevier, 2021)
      he COVID-19 pandemic has been affecting all aspects of peoples’ lives globally, impacting the socio-economic, cultural, health and educational aspects of lives. One of these socio-economic, cultural and health aspects of ...

    • Ruptured Obturator Internus Muscle Abscess Causing Extensive Retroperitoneal Necrosis 

      Zablon Bett (Hindawi, 2020)
      Obturator internus muscle (OIM) abscess occurs rarely in adults. Accurate diagnosis is often hindered and delayed due to the deep location of the abscess and the nonspecific clinical features. Even of rarer occurrence is ...

    • Performance of a rapid antigen test for SARS-CoV-2 in Kenya 

      Simon N.Onsongo, KephasOtieno ,Shannenvan Duijn,EmilyAdams,Mervis Omollo,Isdora A.Odero,AlloysK'Oloo,Nathalie Houbene,Emmanuel ,Milimo RobertAroka,Hellen C.Barsosiob,Fredrick Oluoch,Albert Odhiambo,Simon Kariuki,Tobias F. Rinkede Witce (Elsevier, 2022)
      Testing for SARS-CoV-2 in resource-poor settings remains a considerable challenge. Gold standard nucleic acid tests are expensive and depend on availability of expensive equipment and highly trained laboratory staff. ...

    • The Potential of Differentiation-Related Gene-1 (DRG1) as a Biomarker for Metastasis of Estrogen Receptor-Positive Breast Cancer 

      Hillary Bor , Esther N. Maina , Benson Nyambega , Kirtika Tushar Patel , Charles Ochieng’ Olwal , Walter Nalyanya and Yahaya Gavamukulya (Journal of Advances in Medicine and Medical Research(JAMMR), 2021)
      Breast cancer is major burden worldwide and the majority of breast cancers express estrogen receptors (ER) suggesting a high dependence on estrogen hormone. Age is among the major determinants of breast cancer development, ...

    • Heart disease and stroke statistics—2017 update: a report from the American Heart Association 

      Emelia J Benjamin, Michael J Blaha, Stephanie E Chiuve, Mary Cushman, Sandeep R Das, Rajat Deo, Sarah D De Ferranti, James Floyd, Myriam Fornage, Cathleen Gillespie, Carmen R Isasi, Monik C Jimenez, Lori Chaffin Jordan, Suzanne E Judd, Daniel Lackland, Judith H Lichtman, Lynda Lisabeth, Simin Liu, Chris T Longenecker, Rachel H Mackey, Kunihiro Matsushita, Dariush Mozaffarian, Michael E Mussolino, Khurram Nasir, Robert W Neumar, Latha Palaniappan, Dilip K Pandey, Ravi R Thiagarajan, Mathew J Reeves, Matthew Ritchey, Carlos J Rodriguez, Gregory A Roth, Wayne D Rosamond, Comilla Sasson, Amytis Towfighi, Connie W Tsao, Melanie B Turner, Salim S Virani, Jenifer H Voeks, Joshua Z Willey, John T Wilkins, Jason HY Wu, Heather M Alger, Sally S Wong, Paul Muntner (Lippincott Williams & Wilkins, 2017)
      Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together in a single document ...

    • Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study) 

      Liesl Zühlke, Mark E Engel, Ganesan Karthikeyan, Sumathy Rangarajan, Pam Mackie, Blanche Cupido, Katya Mauff, Shofiqul Islam, Alexia Joachim, Rezeen Daniels, Veronica Francis, Stephen Ogendo, Bernard Gitura, Charles Mondo, Emmy Okello, Peter Lwabi, Mohammed M Al-Kebsi, Christopher Hugo-Hamman, Sahar S Sheta, Abraham Haileamlak, Wandimu Daniel, Dejuma Y Goshu, Senbeta G Abdissa, Araya G Desta, Bekele A Shasho, Dufera M Begna, Ahmed ElSayed, Ahmed S Ibrahim, John Musuku, Fidelia Bode-Thomas, Basil N Okeahialam, Olukemi Ige, Christopher Sutton, Rajeev Misra, Azza Abul Fadl, Neil Kennedy, Albertino Damasceno, Mahmoud Sani, Okechukwu S Ogah, Taiwo Olunuga, Huda HM Elhassan, Ana Olga Mocumbi, Abiodun M Adeoye, Phindile Mntla, Dike Ojji, Joseph Mucumbitsi, Koon Teo, Salim Yusuf, Bongani M Mayosi (Oxford University Press, 2015)
      This prospective registry enrolled 3343 patients (median age 28 years, 66.2% female) presenting with RHD at 25 hospitals in 12 African countries, India, and Yemen between January 2010 and November 2012. The majority (63.9%) ...

    • Duffy Antigen/Receptor for Chemokines (DARC): Is There a Role in Prostate Cancer?. 

      Samuel B.AnyonaBS, ShiyanZhengMD,ThomasWheelerMD,MichaelIttmannMD, Teresa G.HayesMD, Martha P.MimsMD, (science direct, 2005)
      Introduction: The Duffy blood group antigens function as chemokine receptors and as receptors for several species of malarial parasites. Approximately 70% of African Americans are Duffy negative as a result of a single ...

    • Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia 

      Samuel B Anyona, Prakasha Kempaiah, Evans Raballah, Gregory C Davenport, Tom Were, Stephen N Konah, John M Vulule, James B Hittner, Charity W Gichuki, John M Ong'echa, Douglas J Perkins (Wiley Subscription Services, Inc., A Wiley Company, 2012)
      In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children aged <48 months and manifests as severe malarial anemia [SMA; hemoglobin (Hb) < 6.0 g/dL]. Induction of high levels of ...

    • Reduced interferon (IFN)-α conditioned by IFNA2 (− 173) and IFNA8 (− 884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all … 

      Prakasha Kempaiah, Samuel B Anyona, Evans Raballah, Gregory C Davenport, Tom Were, James B Hittner, John M Ong’echa, Douglas J Perkins (Springer-Verlag, 2012)
      Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ...

    • The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis 

      Douglas J. PerkinsEmail authorTom WereSamuel AnyonaJames B. HittnerPrakasha KempaiahGregory C. DavenportJohn Michael Ong’echa (Springer, 2012)
      Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ...