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Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya

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dc.contributor.author Vandana Thathy, JoAnn M Moulds, Bernard Guyah, Walter Otieno, José A Stoute
dc.date.accessioned 2020-11-18T07:12:01Z
dc.date.available 2020-11-18T07:12:01Z
dc.date.issued 2005
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2818
dc.description.abstract Background: It has been hypothesized that the African alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. Methods: To test this hypothesis, children in western Kenya with severe malaria-associated anaemia or cerebral malaria were matched to symptomatic uncomplicated malaria controls by age and gender. Swain-Langley and McCoy blood group alleles were determined by restriction fragment length polymorphism and conditional logistic regression was carried out. Results: No significant association was found between the African alleles and severe malariaassociated anaemia. However, children with Sl2/2 genotype were less likely to have cerebral malaria (OR = 0.17, 95% CI 0.04 to 0.72, P = 0.02) than children with Sl1/1. In particular, individuals with Sl2/2 McCa/b genotype were less likely to have cerebral malaria (OR = 0.18, 95% CI 0.04 to 0.77, P = 0.02) than individuals with Sl1/1 McCa/a. Conclusion: These results support the hypothesis that the Sl2 allele and, possibly, the McCb allele evolved in the context of malaria transmission and that in certain combinations probably confer a survival advantage on these populations. en_US
dc.publisher BioMed Central en_US
dc.title Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya en_US
dc.type Article en_US


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