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Utility of CT scan and CA 19-9 in Predicting Non Resectability in Malignant Obstructive Jaundice . Feb 2014. :1. 22-27.

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dc.contributor.author Kaisha W Bitta C, Githaiga J
dc.date.accessioned 2020-09-04T10:01:45Z
dc.date.available 2020-09-04T10:01:45Z
dc.date.issued 2014-02
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2738
dc.description.abstract Background: Most patients with malignant obstructive jaundice (MOJ) present with non-resectable disease. Non curative laparotomy has been associated with adverse outcome. There is need to predict non-resectable disease and prepare patients for planned palliative procedures. Objective: To study the utility of Ca 19-9 serum levels and CT scan in predicting the non-resectability of MOJ tumours at Kenyatta National Hospital. Methods: Eligible consenting patients were recruited. All had a CT scan of the abdomen and serum CA 19-9 levels determined preoperatively and staging was done using the LRCC criteria. At surgery, intraoperative findings were then compared in terms of non-resectability with the preoperative CT scan prediction and the CA 19-9 levels. Results: A total of 49 patients were recruited into the study. During the study, 14 patients were later excluded due to inadequate information of imaging, non-surgical intervention or pre-operative death. At a confidence level of 95%, CA 19-9 level of 466 has 92.3% sensitivity and 100% specificity indicative of non resectability in MOJ lesions. When compared with intra-operative findings on non-resectability, the cut off level of 466 has a positive and negative predictive value of CA19-9 was 100% and 71.4%, respectively. CT scan had 85.2% sensitivity and 100% specificity on predicting non resectability of MOJ lesions, 84% sensitivity in detecting nodal involvement but predicted only 33% of liver metastases. Conclusion: Combining CA 19-9 levels and CT scan are useful tools in detecting non resectability of MOJ lesions preoperatively en_US
dc.subject Malignant obstructive jaundice, non resectability, CA 19-9 CT scan. en_US
dc.title Utility of CT scan and CA 19-9 in Predicting Non Resectability in Malignant Obstructive Jaundice . Feb 2014. :1. 22-27. en_US
dc.type Article en_US


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