• Login
    • Login
    Advanced Search
    View Item 
    •   Maseno IR Home
    • Journal Articles
    • School of Public health & Community Development
    • Department of Public Health
    • View Item
    •   Maseno IR Home
    • Journal Articles
    • School of Public health & Community Development
    • Department of Public Health
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Polymorphic Variability in the 3'Untranslated Region (UTR) of IL12B is associated with Susceptibility to Severe Anaemia in Kenyan Children with Acute Plasmodium...

    Thumbnail
    Publication Date
    2005
    Author
    Raballah
    Ong'echa, JM
    Kempaiah, PM
    Anyona, SB
    Were, T
    Davenport, GC
    Konah, S
    Vulule, JM
    Ouma, C
    Hittner, James B
    Perkins, DJ
    Metadata
    Show full item record
    Abstract/Overview
    Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children that lack naturally-acquired malarial immunity, such as the population examined here. Consistent with the fact that elevated interleukin (IL)-12 is an important component of the innate immune response that provides protective immunity against malaria, we have previously shown that suppression of IL-12 in African children is associated with the development of severe malarial anaemia (SMA). Since the role of IL12B variants in conditioning susceptibility to SMA remains largely unexplored, the association between a single nucleotide polymorphism (1188A→ C, rs3212227), SMA (Hb< 6.0 g/dL), circulating IL-12p40/p70 levels, and longitudinal clinical …
    Permalink
    https://repository.maseno.ac.ke/handle/123456789/210
    Collections
    • Department of Public Health [234]

    Maseno University. All rights reserved | Copyright © 2022 
    Contact Us | Send Feedback

     

     

    Browse

    All of Maseno IRCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Maseno University. All rights reserved | Copyright © 2022 
    Contact Us | Send Feedback