Show simple item record

dc.contributor.authorOng'echa, JM
dc.contributor.authorKempaiah, PM
dc.contributor.authorAnyona, SB
dc.contributor.authorWere, T
dc.contributor.authorDavenport, GC
dc.contributor.authorKonah, S
dc.contributor.authorVulule, JM
dc.contributor.authorOuma, C
dc.contributor.authorHittner, James B
dc.contributor.authorPerkins, DJ
dc.description.abstractPlasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children that lack naturally-acquired malarial immunity, such as the population examined here. Consistent with the fact that elevated interleukin (IL)-12 is an important component of the innate immune response that provides protective immunity against malaria, we have previously shown that suppression of IL-12 in African children is associated with the development of severe malarial anaemia (SMA). Since the role of IL12B variants in conditioning susceptibility to SMA remains largely unexplored, the association between a single nucleotide polymorphism (1188A→ C, rs3212227), SMA (Hb< 6.0 g/dL), circulating IL-12p40/p70 levels, and longitudinal clinical …en_US
dc.publisherBioMed Centralen_US
dc.titlePolymorphic Variability in the 3'Untranslated Region (UTR) of IL12B is associated with Susceptibility to Severe Anaemia in Kenyan Children with Acute Plasmodium...en_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record