A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory S...
Publication Date
2014-06-10Author
Ogola, George O
Ouma, Collins
Jura, Walter G
Muok, Erick O
Colebunders, Robert
Mwinzi, Pauline N
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Show full item recordAbstract/ Overview
Background Human Immunodeficiency Virus (HIV) and Schistosomiasis co-infection is
common among residents at the shores of Lake Victoria in Kenya. About 36% of this
population initiating antiretroviral therapy (ART) experience Immune Reconstitution
Inflammatory Syndrome (IRIS) that complicates recovery. Several IL-23R alleles have been
associated with susceptibility to both autoimmune and inflammatory diseases through T-
helper type 17 (TH 17) cells. However, whether or not variants within the IL-23R increase
susceptibility to IRIS in western Kenya is unknown. The objective of the current study was to
determine the association between IL-23R gene polymorphisms, CD4+ cell counts and HIV
RNA levels and IRIS in HIV and Schistosoma mansoni co-infected patients undergoing
highly active anti-retroviral therapy (HAART). Methods A three-month case–control study …