A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory S...
dc.contributor.author | Ogola, George O | |
dc.contributor.author | Ouma, Collins | |
dc.contributor.author | Jura, Walter G | |
dc.contributor.author | Muok, Erick O | |
dc.contributor.author | Colebunders, Robert | |
dc.contributor.author | Mwinzi, Pauline N | |
dc.date.accessioned | 2018-01-22T12:52:03Z | |
dc.date.available | 2018-01-22T12:52:03Z | |
dc.date.issued | 2014-06-10 | |
dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/182 | |
dc.description.abstract | Background Human Immunodeficiency Virus (HIV) and Schistosomiasis co-infection is common among residents at the shores of Lake Victoria in Kenya. About 36% of this population initiating antiretroviral therapy (ART) experience Immune Reconstitution Inflammatory Syndrome (IRIS) that complicates recovery. Several IL-23R alleles have been associated with susceptibility to both autoimmune and inflammatory diseases through T- helper type 17 (TH 17) cells. However, whether or not variants within the IL-23R increase susceptibility to IRIS in western Kenya is unknown. The objective of the current study was to determine the association between IL-23R gene polymorphisms, CD4+ cell counts and HIV RNA levels and IRIS in HIV and Schistosoma mansoni co-infected patients undergoing highly active anti-retroviral therapy (HAART). Methods A three-month case–control study … | en_US |
dc.publisher | BioMed Central | en_US |
dc.title | A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory S... | en_US |
dc.type | Article | en_US |
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