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dc.contributor.authorOgola, George O
dc.contributor.authorOuma, Collins
dc.contributor.authorJura, Walter G
dc.contributor.authorMuok, Erick O
dc.contributor.authorColebunders, Robert
dc.contributor.authorMwinzi, Pauline N
dc.date.accessioned2018-01-22T12:52:03Z
dc.date.available2018-01-22T12:52:03Z
dc.date.issued2014-06-10
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/182
dc.description.abstractBackground Human Immunodeficiency Virus (HIV) and Schistosomiasis co-infection is common among residents at the shores of Lake Victoria in Kenya. About 36% of this population initiating antiretroviral therapy (ART) experience Immune Reconstitution Inflammatory Syndrome (IRIS) that complicates recovery. Several IL-23R alleles have been associated with susceptibility to both autoimmune and inflammatory diseases through T- helper type 17 (TH 17) cells. However, whether or not variants within the IL-23R increase susceptibility to IRIS in western Kenya is unknown. The objective of the current study was to determine the association between IL-23R gene polymorphisms, CD4+ cell counts and HIV RNA levels and IRIS in HIV and Schistosoma mansoni co-infected patients undergoing highly active anti-retroviral therapy (HAART). Methods A three-month case–control study …en_US
dc.publisherBioMed Centralen_US
dc.titleA non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory S...en_US
dc.typeArticleen_US


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