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Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya
(BioMed Central, 2020-12)
Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P. falciparum endemic regions such as western ...
National stakeholder preferences for next-generation rotavirus vaccines: Results from a six-country study
(Elsevier, 2022-01-21)
Currently available live, oral rotavirus vaccines (LORVs) have significantly reduced severe rotavirus hospitalizations and deaths worldwide. However, LORVs are not as effective in low- and middle-income countries (LMIC) ...
Caffeine for the care of preterm infants in sub-Saharan Africa: a missed opportunity?
(BMJ Specialist Journals, 2021-12-01)
In 2019, 2.4 million neonates (infants< 28 days of age) died globally. Of these, over 80% were preterm infants (< 37 weeks gestation), with the majority born in low-income and middle-income countries. 1 Complications of ...
Immunophenotypic Characterization of ART-naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya
(Journal of Clinical Immunology and Research, 2020-11-12)
Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function ...
Healthcare provider perspectives on delivering next generation rotavirus vaccines in five low-to-middle-income countries
(Public Library of Science, 2022-06-23)
Live oral rotavirus vaccines (LORVs) have significantly reduced rotavirus hospitalizations and deaths worldwide. However, LORVs are less effective in low- and middle-income countries (LMICs). Next-generation rotavirus ...
Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya
(BioMed Central, 2021-12)
In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for these ...
Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia
(Peertechz, 2021-01-19)
Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly and adequately treated. In 2018 WHO put
the incidence of P. falciparum Malaria in the African region ...
Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS, S/AS01E …
(BioMed Central, 2021-04-26)
The lack of background disease incidence rates in sub-Saharan countries where the RTS,S/AS01E
malaria vaccine is being implemented may hamper the assessment of vaccine safety and effectiveness. This study
aimed to document ...
Case Report: An unusual case of bee envenomation presenting with acute kidney injury, cavernous venous thrombosis and multiple episodes of convulsions
(Peertechz, 2020-11-07)
Bee stings are common in the tropics and cause minor problems but may occasionally cause severe anaphylactoid reactions.
Summary of clinical case: We present a case of M.O.O., an 8-year-old boy who was stung three times ...
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
(BioMed Central, 2022)
Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte ...