Renal Biochemical Marker Changes in Restorative Activities of Curcuma longa on Sildenafil Induced Nephrotoxicity Among Male Albino Rats

Abstract

Nephrotoxicity is the rapid deterioration of kidney function due to altered histoarchitecture and drug clearance characterized by increased levels of renal biochemical markers. Sildenafil is among the drugs postulated to cause nephrotoxicity if taken over a long period of time or as an overdose as it interferes with the kidney histoarchitecture. Curcuma longa is a traditional herbal plant which is used in diet, treatment of diabetes, dermatological conditions and renal diseases.