Department of Biomedical Sciences: Recent submissions
Now showing items 41-60 of 81
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Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya
(PLOS, 2021)Non-typhoidal Salmonella (NTS) is a major global health concern that often causes blood stream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to ... -
Mechanisms and targets of Fcγ-receptor mediated immunity to malaria sporozoites
(Nature Communications, 2021)A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of antibody-mediated immunity is crucial for developing vaccines with high efficacy. Here, we ... -
Qualitative analysis of phytoconstituents in tragia brevipes plant
(International Journal of Pharmaceutical Research & Analysis, 2013)The study was conducted to analyze the phytoconstituents of Tragia brevipes plant leaves. The plant samples were extracted using methanol and water in the ratio 9:1. The phytoconstituents study was done using standard ... -
Antimalarials: Review of Plasmepsins as Drug Targets and HIV Protease Inhibitors Interactions
(Bentham Science Publishers, 2018)Malaria is a major global health concern with the majority of cases reported in regions of South-East Asia, Eastern Mediterranean, Western Pacific, the Americas, and Sub-Saharan Africa. The World Health Organization (WHO) ... -
Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
(Frontier in Immunology, 2018)Vaccines that target Plasmodium falciparum gametocytes have the potential to reduce malaria transmission and are thus attractive targets for malaria control. However, very little is known about human immune responses to ... -
Safe Anesthesia Care in Western Kenya: A Preliminary Assessment of the Impact of Nurse Anesthetists at Multiple Levels of Government Hospitals
(International Anesthesia Research, 2019)BACKGROUND: Only 20% of the surgical burden in eastern sub-Saharan Africa is currently met, leaving >17 million surgical cases annually in need of safe surgery and anesthesia. Similarly, there is an extreme shortage of ... -
Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia
(Scientific Report, 2019)Epstein Barr virus (EBV) is the etiologic agent involved in numerous human cancers. After infecting the host, EBV establishes a latent infection, with low levels of messenger RNA (mRNA) and protein expression, evolved ... -
Status of aflatoxin contamination in cow milk produced in smallholder dairy farms in urban and peri-urban areas of Nairobi County: a case study of Kasarani sub county, Kenya
(Taylor & Francis, 2018)Introduction: Milk consumption in Kenya supersedes other countries in East Africa. However, milk contamination with aflatoxin M1 (AFM1) is common, but the magnitude of this exposure and the health risks are poorly ... -
Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
(Springer, 2017)Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of ... -
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
(BMC, 2020)Background: Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya
(2020)Background: Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P. falciparum endemic regions such ... -
Epidemiological patterns and antimicrobial resistance of bacterial diarrhea among children in Nairobi City, Kenya
(RIGLD, Research Institute for Gastroenterology and Liver Diseases, 2020)Aim:Determine the prevalence of enteric bacterial pathogens and their antimicrobial resistance among diarrheic children in Nairobi City, Kenya. Background: Regardless of enteric bacterial pathogens being a major ... -
Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
(Biochemistry and Biophysics Reports, 2022)Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the malarial parasite product, hemozoin (PfHz), by circulating phagocytic ... -
Pyrethroid resistance in Anopheles gambiae s.s. and Anopheles arabiensis in western Kenya: phenotypic, metabolic and target site characterizations of three populations
(Wiley Online Library, 2012)Field and laboratory investigations revealed phenotypic, target site and metabolic resistance to permethrin in an Anopheles gambiae s.s. (Diptera: Culicidae) population in Bungoma District, a region in western Kenya in ... -
Habitat selection and vertical inheritance drive archaeal community structure in arthropod guts
(ECOLOGICAL AND EVOLUTIONARY DRIVERS OF MICROBIAL COMMUNITY STRUCTURE IN TERMITE GUTS, 2015)The arthropod gut is streamlined to anaerobically mineralize mostly plant-derived organic matter. In only five major arthropod groups (millipedes, scarab beetle larvae, cockroaches, and lower and higher termites) are ... -
Compartment-specific bacterial communities in higher termites
(M icroha bitat-specificity of the hindgut microbiota in higher termites, 2013)The higher termite gut is a highly structured habitat and shows the presence of spatially separated compartments. The differences in physicochemical parameters between the compartments, most importantly pH, play an important ... -
Isolation and characterization of actinobacteria with potential for control of fusarium spp and colletotrichum kahawae
(Jomo Kenyatta University of Agriculture and Technology, 2007)Smallholder subsistence farming is important in the production of food crops for basic livelihoods and income generation in rural areas. However, yields have remained low due to high disease, weed and pest incidences. ... -
Isolation and characterization of Streptomyces species with antifungal activity from selected national parks in Kenya
(African Journal of Microbiology Research, 2010)Microorganisms and their natural products are potentially important for the biological control of crop diseases without detrimental effects to the environment. In this study, acetonitrile-methanol extracts of 361 ... -
Growth characteristics and production of secondary metabolites from selected novel Streptomyces species isolated from selected Kenyan national parks
(JKUAT ANNUAL SCIENTIFIC CONFERENCE PROCEEDINGS, 2010)The aim of study was to characterize growth of novel Streptomyces isolates as well as the secondary metabolites they were producing. Four Streptomyces isolates from Chyulu National Park (Chy 4 -10, Chy 15-10, Chy 15-5 and ... -
Optimization of growth conditions and characterization of enzymatic activity of selected novel Streptomyces species from Kenyan soils
(Scientific Conference Proceedings, 2012-06-14)This study was aimed at unveiling and assessing protease, esterase, amylase and lipase enzymes from selected novel Streptomyces species with biotechnological interest. Four Streptomyces isolates from Jomo Kenyatta University ...