Department of Biomedical Sciences: Recent submissions
Now showing items 1-20 of 91
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Disproportionate impact of COVID-19 severity and mortality on hospitalized American Indian/Alaska Native patients
(Oxford University Press, 2023-08)Epidemiological data across the United States of America illustrate health disparities in COVID-19 infection, hospitalization, and mortality by race/ethnicity. However, limited information is available from prospective ... -
Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism
(MDPI, 2024-10-03)Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission zones. This study explored the entire expressed human transcriptome in ... -
Methodological assessment for efficient collection of Schistosoma mansoni environmental DNA and improved schistosomiasis surveillance in tropical wetlands
(Elsevier, 2024-10-28)Schistosomiasis, caused by trematodes of genus Schistosoma, is among the most seriously neglected tropical diseases. Although rapid surveillance of risk areas for Schistosoma transmission is vital to control schistosomiasis, ... -
Impact of health education intervention on the patients’ adherence to malaria Artemisinin-based combination therapy in Kamuli District, Uganda
(Research square, 2024-05-09)Global malaria control programmes such as approaches to community engagements to deliver malaria control interventions have been successful in controlling malaria. Malaria remains a disease of public health importance ... -
The influence of demographic and socio-economic factors on non-vaccination, under-vaccination and missed opportunities for vaccination amongst children 0–23 months in Kenya for the period 2003–2014
(Public Library of Science, 2024-05-30)Vaccination is crucial in reducing child mortality and the prevalence of Vaccine-Preventable-Diseases (VPD), especially in low-and-middle-income countries like Kenya. However, non-vaccination, under-vaccination, and missed ... -
Enhancing cervical cancer knowledge among women of reproductive age: a dialogue-based community health education intervention in rural Kisumu County, Kenya
(BioMed Central, 2024-06-06)Cervical cancer is a leading cause of cancer death among women of reproductive age despite being treatable if it is diagnosed early. Early diagnosis is possible through regular screening through the public health system. ... -
Entire expressed peripheral blood transcriptome in pediatric severe malarial anemia
(Nature Publishing Group UK, 2024-06-12)This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, compares the entire expressed whole blood host transcriptome between Kenyan children (3-48 mos.) ... -
Improving cervical cancer screening rates among women of reproductive age in rural Kisumu County through dialogue-based community health education
(eCancer, 2024-06-13)Low- and middle-income countries continue to bear the burden of cervical cancer partly due to low uptake of screening services. Interventions through the media to increase demand for screening services among women of ... -
Seasonal Variations in Food Insecurity Prevalence of Mother-Child Dyads in Seme Sub-County, Kisumu, Kenya
(East African Journal of Health and Science, 2024-06-17)Food insecurity remains a major impediment to the attainment of adequate health outcomes among the population. This is attributable to the adverse implications that food insecurity poses on the nutritional status of the ... -
Increased sensitivity of malaria parasites to common antimalaria drugs after the introduction of artemether-lumefantrine: Implication of policy change and implementation of more effective drugs in fight against malaria
(Public Library of Science, 2024-06-20)Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi-drug resistance protein 1 (Pfmrp1) gene have previously been reported to confer resistance to Artemisinin-based Combination Therapies (ACTs) in ... -
Evaluating Antiplasmodial and Antimalarial Activities of Soybean (Glycine max) Seed Extracts on P. falciparum Parasite Cultures and P. berghei-Infected Mice
(Hindawi, 2020-02-17)Plasmodium parasite resistance to artemisinin-based combination therapies (ACTs) calls for development of new, affordable, safe, and effective antimalarial drugs. Studies conducted previously on soybean extracts have ... -
Antimalarial activity of Nigella sativa L. Seed extracts and selection of resistance in Plasmodium berghei ANKA in a mouse model
(Hindawi Limited, 2021-02-03)Chemotherapy plays a crucial role in malaria control. However, the main obstacle to treatment has been the rise of parasite resistance to most antimalarial drugs. Artemisinin-based combination therapies (ACTs) remain the ... -
The Potential of Differentiation Related Gene 1 DRG1) as a Biomarker for Metastasis of Estrogen Receptor Positive Breast Cancer
(Journal of Advances in Medicine and Medical Research, 2021-10-07)Breast cancer is major burden worldwide and the majority of breast cancers express estrogen receptors (ER) suggesting a high dependence on estrogen hormone. Age is among the major determinants of breast cancer development, ... -
Seasonality of associations between production of indigenous foods and food security status of mother-child dyads in Kisumu County, Kenya
(BioMed Central, 2024-01-10)Food insecurity is a major predicament for rural populations, especially mothers and children, whose livelihoods are often dependent on rain-fed agriculture. Indigenous foods have the potential of mitigating food insecurity ... -
Efficacy of the PermaNet Dual compared to the Interceptor G2 and the PermaNet 3.0 in experimental huts in Siaya County, western Kenya.
(Research Square, 2024-01-25)Pyrethroid-chlorfenapyr nets have shown significant epidemiological impact over pyrethroid-only and pyrethroid plus piperonal-butoxide (PBO) in Africa. Here we describe a non-inferiority evaluation of PermaNet Dual, a ... -
Barriers and Misconceptions Hindering Reduction of Intestinal Schistosomiasis in Mbita Sub-County, Western Kenya
(Research Square, 2024-02-05)Community and individual participation are crucial for the success of schistosomiasis control. The World Health Organization (WHO) has highlighted the importance of enhanced sanitation, health education, and mass treatment ... -
Trends of non-vaccination, under-vaccination and missed opportunities for vaccination (2003–2014) amongst children 0–23 months in Kenya
(Public Library of Science, 2024-02-06)Vaccines are effective and cost-effective. Non-vaccination, under-vaccination, and missed opportunities for vaccination (MOV), have contributed to incomplete vaccination coverage in Kenya. Analyzing their trends is essential ... -
Coagulation hallmark indicators of menorrhagia in a comparative study between menorrhagic and healthy women attending Bungoma County Referral Hospital in Kenya
(Research Square, 2024-02-13)Despite the significant burden of menorrhagia among women in Western Kenya, it remains unknown whether coagulation disorders are one of the important underlying causes of this condition in the region. This study evaluated ... -
Factors influencing patients’ adherence to malaria Artemisinin-based combination therapy treatment in Kamuli District, Uganda
(Research Square, 2023-10-06)Patients’ adherence to prescribed Artemisinin-based Combination Therapy (ACT) treatment is a key malaria control strategy. To accelerate and realize a malaria free country, malaria management measures remain a key public ... -
Comparison of Different Trapping Methods to Collect Malaria Vectors Indoors and Outdoors in Western Kenya
(Research square, 2023-08-31)Enhanced vector surveillance, is one of the 4 pillars of the WHO’s global vector control response (2017–2030). Human landing catches are the gold standard for entomological surveys but are difficult to implement and expose ...