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Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
(Biochemistry and Biophysics Reports, 2022)
Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the malarial parasite product, hemozoin (PfHz), by circulating phagocytic ...
Sero-Prevalence and Molecular Analysis of Brucellosis in Livestock Keepers and Domestic Ruminants in Baringo County, Kenya
(Research square, 2022)
Brucellosis is widely distributed in more than 170 countries around the world, where it poses
a huge threat to animal husbandry and human health. Brucellosis is a worldwide re-emerging zoonotic
disease that poses serious ...
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
(BioMed Central, 2022)
Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte ...
Impact of integrated water, sanitation, hygiene, health and nutritional interventions on diarrhoea disease epidemiology and microbial quality of water in a resource-constrained setting in Kenya: A controlled intervention study
(Wiley online library, 2022)
We assessed the impact of water, hygiene and sanitation (WASH), maternal,new-born and child health (MNCH), nutrition and early childhood development (ECD) on diarrhoea and microbial quality of water in a resource-constrained ...
Genetic differentiation in East African ethnicities and its relationship with endurance running success
(Public Library of Science, 2022)
Since the 1960s, East African athletes, mainly from Kenya and Ethiopia, have dominated long-distance running events in both the male and female categories. Further demographic studies have shown that two ethnic groups are ...
Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children
(Frontiers, 2022)
Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya.
The prevalence and management strategies of gestational urinary tract infections (UTI) in Kisumu County, Kenya
(Cold Spring Harbor Laboratory Press, 2022)
Urinary tract infections (UTI) contribute to substantive proportions of adverse pregnancy outcomes. Current national statistics in Kenya show high maternal mortality (488/100,000) and neonatal mortality (24/1,000) rates. ...
Evidence of co-exposure with Brucella spp, Coxiella burnetii, and Rift Valley fever virus among various species of wildlife in Kenya
(Public Library of Science, 2022-09)
Co-infection, especially with pathogens of dissimilar genetic makeup, may result in a more
devastating impact on the host. Investigations on co-infection with neglected zoonotic pathogens in wildlife are necessary to ...
Influence of landscape heterogeneity on entomological and parasitological indices of malaria in Kisumu, Western Kenya
(BioMed Central, 2022)
Identification and characterization of larval habitats, documentation of Anopheles spp. composition and abundance, and Plasmodium spp. infection burden are critical components of integrated vector management. The present ...
Prevalence of preconception care provision in Kisumu county-Kenya
(Cold Spring Harbor Laboratory Press, 2022)
‘Preconception care’ (PCC) is the provision of biomedical, behavioral and social
health interventions to women and couples before conception occurs. The PCC, is valuable and
key in preventing and controlling non-communicable ...