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Mechanisms and targets of Fcγ-receptor mediated immunity to malaria sporozoites
(Nature Communications, 2021)
A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of antibody-mediated immunity is crucial for developing vaccines with high efficacy. Here, we ...
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya
(PLOS, 2021)
Non-typhoidal Salmonella (NTS) is a major global health concern that often causes blood stream infections in areas of the world affected by malnutrition and comorbidities such as
HIV and malaria. Developing a strategy to ...
Synergism in Antiplasmodial Activities of Artemether and Lumefantrine in Combination with Securidaca longipedunculata Fresen (Polygalaceae)
(MDPI, 2021)
Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden. Since the deployment of artemisinin-based ...
Effects of Achyranthes aspera, Bidens pilosa and Ajuga remota Leaf extracts on the blood glucose levels and hemoparameters in male goats treated with Alloxan
(AJOL, 2021)
Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus the disease constitutes a major health concern. Presently, it is an incurable metabolic disorder which affects about 2.8% of the global ...
Immunohistochemical Analysis of Prostein Expression in Archived Prostatic Core Biopsies from Prostate Cancer Patients in Western Kenya
(Research Square, 2021)
Prostate cancer is the leading cause of cancer-associated mortality in men. Most of the current
biomarkers for detection of the disease have low sensitivity and specificity. Prostein is a newly reported
prostate cancer ...
Determinants of tuberculosis treatment interruption among patients in Vihiga County, Kenya
(PLOS ONE, 2021)
Despite robust Tuberculosis (TB) program with effective chemotherapy and high coverage,
treatment interruption remains a serious problem. Interrupting TB treatment means that
patients remain infectious for longer time ...
Incidence of Brucella infection in various livestock species raised under the pastoral production system in Isiolo County, Kenya
(Springer, 2021)
We implemented a longitudinal study to determine the incidence of Brucella infection in cattle, camels, sheep and goats that were being raised in a pastoral area in Isiolo County, Kenya. An initial cross-sectional survey ...
The Potential of Differentiation Related Gene 1 DRG1) as a Biomarker for Metastasis of Estrogen Receptor Positive Breast Cancer
(Journal of Advances in Medicine and Medical Research, 2021-10-07)
Breast cancer is major burden worldwide and the majority of breast cancers express estrogen receptors (ER) suggesting a high dependence on estrogen hormone. Age is among the major determinants of breast cancer development, ...
Antimalarial activity of Nigella sativa L. Seed extracts and selection of resistance in Plasmodium berghei ANKA in a mouse model
(Hindawi Limited, 2021-02-03)
Chemotherapy plays a crucial role in malaria control. However, the main obstacle to treatment has been the rise of parasite resistance to most antimalarial drugs. Artemisinin-based combination therapies (ACTs) remain the ...