| dc.contributor.author | Angela O.Achienga, Bernard Guyah,Qiuying Cheng,John M.Ong'echa,Collins Ouma,Christophe G.Lambert,Douglas J.Perkins | |
| dc.date.accessioned | 2022-02-18T08:39:20Z | |
| dc.date.available | 2022-02-18T08:39:20Z | |
| dc.date.issued | 2019 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/5007 | |
| dc.description | https://doi.org/10.1016/j.ebiom.2019.06.040 | en_US |
| dc.description.abstract | Leukocyte-associated immunoglobulin like receptor-1 (LAIR1) is a transmembrane inhibitory receptor that influences susceptibility to a myriad of inflammatory diseases. Our recent investigations of severe malarial anaemia (SMA) pathogenesis in Kenyan children discovered that novel LAIR1 genetic variants which were associated with decreased LAIR1 transcripts enhanced the longitudinal risk of SMA and all-cause mortality. | en_US |
| dc.publisher | science direct | en_US |
| dc.subject | Complement component 1qLeukocyte-associated immunoglobulin like receptor-1Leukocyte-associated immunoglobulin like receptor-2Plasmodium falciparum malariaPlasmodium falciparum haemozoinSevere malarial anaemia | en_US |
| dc.title | Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling | en_US |
| dc.type | Article | en_US |
