The role of complement immune response on artemisinin-based combination therapy in a population from malaria endemic region of Western Kenya

Abstract

Naturally acquired immunity (NAI), which is characterized by protection against overt clinical disease and high parasitaemia, is acquired with age and transmission intensity. The role of NAI on the efcacy of anti-malarial drugs, including artemisinin-based combinations used as the frst-line treatment for uncomplicated Plasmodium falciparum, has not been fully demonstrated. This study investigated the role of NAI in response to artemisinin-based combination therapy (ACT), in symptomatic patients living in western Kenya, a high malaria transmission area.