| dc.contributor.author | Christine N. L. Wanjala, Elke Bergmann-Leitner, Hoseah M. Akala, Geoffrey Odhiambo, Bernhards R. Ogutu, Ben Andagalu, Edwin Kamau & Daniel Ochiel | |
| dc.date.accessioned | 2022-02-04T06:14:08Z | |
| dc.date.available | 2022-02-04T06:14:08Z | |
| dc.date.issued | 2020 | |
| dc.identifier.citation | Wanjala, C.N.L., Bergmann-Leitner, E., Akala, H.M. et al. The role of complement immune response on artemisinin-based combination therapy in a population from malaria endemic region of Western Kenya. Malar J 19, 168 (2020). https://doi.org/10.1186/s12936-020-03242-4 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/4863 | |
| dc.description | https://doi.org/10.1186/s12936-020-03242-4 | en_US |
| dc.description | This study demonstrates for the first time there is synergy of complement, pre-existing immunity, and drug treatment in younger patients with symptomatic malaria in a high-transmission area. | |
| dc.description.abstract | Naturally acquired immunity (NAI), which is characterized by protection against overt clinical disease
and high parasitaemia, is acquired with age and transmission intensity. The role of NAI on the efcacy of anti-malarial
drugs, including artemisinin-based combinations used as the frst-line treatment for uncomplicated Plasmodium
falciparum, has not been fully demonstrated. This study investigated the role of NAI in response to artemisinin-based
combination therapy (ACT), in symptomatic patients living in western Kenya, a high malaria transmission area. | en_US |
| dc.publisher | Springer | en_US |
| dc.subject | Malaria antibody, Complement, Malaria immunity, Artemisinin combination therapy, Western Kenya, Malaria holoendemic areas | en_US |
| dc.title | The role of complement immune response on artemisinin-based combination therapy in a population from malaria endemic region of Western Kenya | en_US |
| dc.type | Article | en_US |
