| dc.contributor.author | 38. Portia A. Gracelyn, Mwaniki D. M., Ng’wena A. G. M. and Wanjala P. M | |
| dc.date.accessioned | 2022-01-31T09:35:13Z | |
| dc.date.available | 2022-01-31T09:35:13Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | :2347-565X | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/4806 | |
| dc.description | https://journalarrb.com/index.php/ARRB/article/view/26454/49642 | en_US |
| dc.description.abstract | ToinvestigatethephytochemicalsandtheanticonvulsantactivityoftheethanolleafextractofCulcasiafalcifoliausedinthetraditionalmedicaltreatmentofepilepsy.Methodology:ThephytochemicalscreeningwascarriedoutusingstandardprotocolwhiletheanticonvulsantactivitywasstudiedusingPentylenetetrazoleinmice.Result:ThepreliminaryphytochemicalscreeningcarriedoutontheethanolextractofCulcasiafalcifoliarevealedthepresenceofalkaloids,flavonoids,saponins,tannins,polyphenols,andglycosides.Intheanticonvulsantactivity,therewasasignificant(*p<0.05,**p<0.01)increaseinthemeanlatencyoftonicconvulsion(243.72±6.90*,402.56±5.52**)andsignificant(*p<0.05,OriginalResearchArticle
Portiaetal.;ARRB,29(1): 1-7, 2018; Article no.ARRB.428442**p<0.01)decreaseinthemeandurationoftonicconvulsion(192.62±7.72*,158.99±8.66**)inadose-dependentmanneratthedoseof200and400mg/kgbodywt.respectively.Theextractat400mg/kgbodywt.showed100%protectionagainstmortality.Conclusion:TheresultsofthisstudysuggestthattheethanolleafextractofCulcasiafalcifoliapossessesanticonvulsantactivityinPTZinducedseizureinmice | en_US |
| dc.publisher | Annual Research & Review in Biology | en_US |
| dc.subject | Culcasiafalcifolia;phytochemicals;antiepileptic;pentylenetetrazole | en_US |
| dc.title | PhytochemicalandAntiepilepticActivityoftheEthanolLeafExtractsofCulcasiafalcifoliainPentylenetetrazoleInducedSeizureinMice | en_US |
| dc.type | Article | en_US |
