| dc.contributor.author | Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong’echa, Ann M. Moormann & Jeffrey A. Bailey | |
| dc.date.accessioned | 2022-01-29T08:33:15Z | |
| dc.date.available | 2022-01-29T08:33:15Z | |
| dc.date.issued | 2017 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/4748 | |
| dc.description | https://link.springer.com/content/pdf/10.1186/s12885-017-3711-9.pdf | en_US |
| dc.description.abstract | Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells. | en_US |
| dc.publisher | Springer | en_US |
| dc.subject | Endemic Burkitt lymphoma, miRNA, mRNA, RNA sequencing, Lymphomagenesis | en_US |
| dc.title | Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma | en_US |
| dc.type | Article | en_US |
