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dc.contributor.authorSamuel B. Anyona, Evans Raballah, Qiuying Cheng, Ivy Hurwitz, Caroline Ndege, Elly Munde, Walter Otieno, Philip D. Seidenberg, Kristan A. Schneider, Christophe G. Lambert, Benjamin H. McMahon, Collins Ouma, and Douglas J. Perkins ,
dc.date.accessioned2022-01-21T10:55:59Z
dc.date.available2022-01-21T10:55:59Z
dc.date.issued2021
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/4458
dc.descriptiondoi: 10.3389/fgene.2021.764759en_US
dc.description.abstract: Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic Plasmodium falciparum transmission regions, such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dl] is the primary form of severe disease. Ubiquitination is essential for regulating intracellular processes involved in innate and adaptive immunity. Although dysregulation in ubiquitin molecular processes is central to the pathogenesis of multiple human diseases, the expression patterns of ubiquitination genes in SMA remain unexploreden_US
dc.description.sponsorshipDepartment of Medical Biochemistry, School of Medicine, Maseno University, Maseno, Kenya, 2 University of New Mexico-Kenya Global Health Programs, Kisumu and Siaya, Kenya, 3 Department of Medical Laboratory Sciences, School of Public Health Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, Kakamega, Kenya, 4 Center for Global Health, University of New Mexico, Albuquerque, NM, United States, 5 Department of Clinical Medicine, School of Health Science, Kirinyaga University, Kerugoya, Kenya, 6 Department of Pediatrics and Child Health, School of Medicine, Maseno University, Maseno, Kenya, 7 Department of Emergency Medicine, University of New Mexico, Albuquerque, NM, United States, 8 Department Applied Computer and Bio-Sciences, University of Applied Sciences Mittweida, Mittweida, Germany, 9 Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, United States, 10Department of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno, Kenyaen_US
dc.publisherFrontiers Media SAen_US
dc.subject: ubiquitination, ubiquitin proteasome system, differential gene expression, Plasmodium falciparum, malarial anemiaen_US
dc.titleDifferential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemiaen_US
dc.typeThesisen_US


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