• Survival and Risk Factors for Late Preterm and Early Term Neonates Compared to Full-Term Infants at Garissa County Referral Hospital, Kenya 

  Amolo, Tom; Raballah, Evans; Olayo, Rose; Esendi, C.Gladys; Otieno, Walter (AJOL, 2024-10-31)

  Preterm birth constitutes a significant health burden in Kenya, yet there is hardly any targeted research looking at the survival and specific risk factors associated with birth of late preterm neonates (LPNs) and early ...
• The Walter Reed Project, Kisumu Field Station: Impact of Research on Malaria Policy, Management, and Prevention. 

  Peter M Sifuna, Michal Mbinji, Tina O Lucas, Irene Onyango, Hoseah M Akala, John N Waitumbi, Bernhards R Ogutu, Jack N Hutter, Walter Otieno (The American Journal of Tropical Medicine and Hygiene, 2024-04-23)

  The Walter Reed Project is a collaboration between the Walter Reed Army Institute of Research of the United States Department of Defense and the Kenya Medical Research Institute. The Kisumu field station, comprising four ...
• A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa 

  Sandra Van Puyvelde, Tessa De Block, Sushmita Sridhar, Matt Bawn, Robert A Kingsley, Brecht Ingelbeen, Mathew A Beale, Barbara Barbé, Hyon Jin Jeon, Lisette Mbuyi-Kalonji, Marie-France Phoba, Dadi Falay, Delphine Martiny, Olivier Vandenberg, Dissou Affolabi, Jean Pierre Rutanga, Pieter-Jan Ceyssens, Wesley Mattheus, Wim L Cuypers, Marianne AB Van Der Sande, Se Eun Park, Simon Kariuki, Kephas Otieno, John PA Lusingu, Joyce R Mbwana, Samuel Adjei, Anima Sarfo, Seth O Agyei, Kwaku P Asante, Walter Otieno, Lucas Otieno, Marc C Tahita, Palpouguini Lompo, Irving F Hoffman, Tisungane Mvalo, Chisomo Msefula, Fatimah Hassan-Hanga, Stephen Obaro, Grant Mackenzie, Stijn Deborggraeve, Nicholas Feasey, Florian Marks, Calman A MacLennan, Nicholas R Thomson, Jan Jacobs, Gordon Dougan, Samuel Kariuki, Octavie Lunguya (Nature Publishing Group UK, 2023-10-23)

  Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. ...
• Time to full enteral feeds in hospitalised preterm and very low birth weight infants in Nigeria and Kenya 

  Zainab O Imam, Helen M Nabwera, Olukemi O Tongo, Pauline EA Andang’o, Isa Abdulkadir, Chinyere V Ezeaka, Beatrice N Ezenwa, Iretiola B Fajolu, Martha K Mwangome, Dominic D Umoru, Abimbola E Akindolire, Walter Otieno, Macrine Olwala, Grace M Nalwa, Alison W Talbert, Ismaela Abubakar, Nicholas D Embleton, Stephen J Allen, Neonatal Nutrition Network (NeoNuNet) (Public Library of Science, 2024-03-08)

  Preterm (born < 37 weeks’ gestation) and very low birthweight (VLBW; <1.5kg) infants are at the greatest risk of morbidity and mortality within the first 28 days of life. Establishing full enteral feeds is a vital aspect ...
• Deployment of Rotavirus Vaccine in Western Kenya Coincides with a Reduction in All-Cause Child Mortality: A Retrospective Cohort Study 

  Sifuna, Peter; Shaw, Andrea V; Lucas, Tina; Ogutu, Bernards; Otieno, Walter; Larsen, David A (MDPI, 2023-07-29)

  Rotavirus is an important cause of fatal pediatric diarrhea worldwide. Many national immunization programs began adding rotavirus vaccine following a 2009 World Health Organization recommendation. Kenya added rotavirus ...
• Prostration and the prognosis of death in African children with severe malaria 

  Selidji T Agnandji, Mario Recker, Benjamin Mordmüller, Stephan Glöckner, Akim A Adegnika, Bertrand Lell, Lucas Otieno, Walter Otieno, Seth Owusu-Agyei, Kwaku P Asante, Tsiri Agbenyega, Daniel Ansong, Eusebio Macete, Pedro Aide, Hermann Sorgho, Halidou Tinto, Neema Mturi, John PA Lusingu, Samwel Gesase, Irving Hoffman, Nahya Salim Masoud, Charles R Newton, Kalifa Bojang, Gérard Krause, Peter Gottfried Kremsner (Elsevier, 2023-09-01)

  Malaria is still one of the main reasons for hospitalization in children living in sub-Saharan Africa. Rapid risk stratification at admission is essential for optimal medical care and improved prognosis. Whereas coma, deep ...
• Association among Cases of Women with first degree Family History of Diabetes Mellitus, Previous Macrosomia and Preterm Births, and Pregnancy Weight Gain at Mama Lucy Kibaki Hospital, Nairobi City 

  Muswali Gabriel, Rosebella Onyango, Bernard Guyah, Walter Otieno (EAST AFRICAN NATURE & SCIENCEORGANIZATION, 2023)

  Weight gain during pregnancy is of great concern for most women and obstetricians because of its possible consequences. This concern exists because gestational weight gain that exceeds what is recommended ...
• Association among Cases of Pregnancy Weight Gain, Gestational Diabetes Mellitus and Neonatal Delivery Outcomes at Mama Lucy Kibaki Hospital, Nairobi City 

  Muswali Gabriel, Rosebella Onyango, Bernard Guyah, Walter Otieno (Scientific Research Publishing, 2023)

  Gestational Weight Gain and Gestational Diabetes Mellitus are interrelated and are also closely associated with adverse neonatal deliveries namely macrosomia and preterm births. However, available literature does not ...
• Adverse effects of Lugol’s iodine: Heart failure in a patient with subcutaneous phycomycosis from a resource-limited setting 

  Dean S Karahalios, Andrea Shaw, Bonnke Arunga, Carlee Lenehan, Valentine Sing'oei, Walter Otieno (Elsevier, 2022-09-09)

  Subcutaneous phycomycosis becomes a chronic, debilitating condition if left untreated. Treatment includes oral antifungal therapy, though oral potassium iodide has been used in resource-limited settings. Lugol's iodine has ...
• Assessing the safety, impact and effectiveness of RTS,S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and study set-up 

  Nicolas Praet, Kwaku Poku Asante, Marie-Cecile Bozonnat, Elaine Jacqueline Akité, Patrick Odum Ansah, Laurence Baril, Owusu Boahen, Yolanda Guerra Mendoza, Valerie Haine, Simon Kariuki, Mathieu Lamy, Kenneth Maleta, Randy Mungwira, Latif Ndeketa, Abraham Oduro, Bernhards Ogutu, Fredrick Olewe, Martina Oneko, Mattéa Orsini, Francois Roman, Edith Roset Bahmanyar, Dominique Rosillon, Lode Schuerman, Valentine Sing’oei, Dianne J Terlouw, Stéphanie Wéry, Walter Otieno, Jean-Yves Pirçon (BioMed Central, 2022)

  Following a 30-year development process, RTS,S/AS01E (GSK, Belgium) is the first malaria vaccine to reach Phase IV assessments. The World Health Organization-commissioned Malaria Vaccine Implementation Programme (MVIP) is ...
• Safety profile of the RTS, S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa 

  Yolanda Guerra Mendoza, Elodie Garric, Amanda Leach, Marc Lievens, Opokua Ofori-Anyinam, Jean-Yves Pirçon, Jens-Ulrich Stegmann, Pascale Vandoolaeghe, Lucas Otieno, Walter Otieno, Seth Owusu-Agyei, Jahit Sacarlal, Nahya Salim Masoud, Hermann Sorgho, Marcel Tanner, Halidou Tinto, Innocent Valea, Ali Takadir Mtoro, Patricia Njuguna, Martina Oneko, Godfrey Allan Otieno, Kephas Otieno, Samwel Gesase, Mary J Hamel, Irving Hoffman, Seyram Kaali, Portia Kamthunzi, Peter Kremsner, Miguel Lanaspa, Bertrand Lell, John Lusingu, Anangisye Malabeja, Pedro Aide, Pauline Akoo, Daniel Ansong, Kwaku Poku Asante, James A Berkley, Samuel Adjei, Tsiri Agbenyega, Selidji Todagbe Agnandji, Lode Schuerman (Taylor & Francis, 2019-10-03)

  A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-Saharan Africa showed RTS, S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children ...
• Estimating Annual Fluctuations in Malaria Transmission Intensity and in the Use of Malaria Control Interventions in Five Sub-Saharan African Countries 

  Youssouf Kabore, Mathieu Lamy, John Lusingu, Anangisye Malabeja, Petra Mens, Matt ea Orsini, Lucas Otieno, Walter Otieno, Seth Owusu-Agyei, Janet Oyieko, Jean-Yves Pirçon, Nicolas Praet, François Roman, Ali Sie, Valentine SingLoei, Sodiomon B Sirima, Khadime Sylla, Roger Tine, Alfred B Tiono, Mathilda Tivura, Effua Usuf (The American Society of Tropical Medicine and Hygiene, 2020)

  RTS,S/AS01E malaria vaccine safety, effectiveness, and impact will be assessed in pre- and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinate ...
• Safety and immunogenicity of the RTS, S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa 

  Lucas Otieno, Yolanda Guerra Mendoza, Samuel Adjei, Tsiri Agbenyega, Selidji Todagbe Agnandji, Pedro Aide, Pauline Akoo, Daniel Ansong, Kwaku Poku Asante, James A Berkley, Samwel Gesase, Mary J Hamel, Irving Hoffman, Seyram Kaali, Portia Kamthunzi, Simon Kariuki, Peter Kremsner, Miguel Lanaspa, Bertrand Lell, Marc Lievens, John Lusingu, Anangisye Malabeja, Nahya Salim Masoud, Ali Takadir Mtoro, Patricia Njuguna, Opokua Ofori-Anyinam, Godfrey Allan Otieno, Walter Otieno, Seth Owusu-Agyei, Lode Schuerman, Hermann Sorgho, Marcel Tanner, Halidou Tinto, Innocent Valea, Pascale Vandoolaeghe, Jahit Sacarlal, Martina Oneko (Elsevier, 2020-01-22)

  We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African ...
• Estimating annual fluctuations in malaria transmission intensity and in the use of malaria control interventions in five sub-Saharan African countries 

  S RTS, Elisha Adeniji, Kwaku Poku Asante, Owusu Boahen, Guillaume Compaoré, Boubacar Coulibaly, Seyram Kaali, Youssouf Kabore, Mathieu Lamy, John Lusingu, Anangisye Malabeja, Petra Mens, Mattéa Orsini, Lucas Otieno, Walter Otieno, Seth Owusu-Agyei, Janet Oyieko, Jean-Yves Pirçon, Nicolas Praet, François Roman, Ali Sie, Valentine Sing’oei, Sodiomon B Sirima, Khadime Sylla, Roger Tine, Alfred B Tiono, Mathilda Tivura, Effua Usuf, Stéphanie Wéry (The American Society of Tropical Medicine and Hygiene, 2020-11)

  RTS, S/AS01 E malaria vaccine safety, effectiveness, and impact will be assessed in pre-and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinated ...
• Immunophenotypic Characterization of ART-naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya 

  Jew Ochola, Jackson C Korir, Walter Otieno, Julie Ake, Christina Polyak, David H Mulama (Journal of Clinical Immunology and Research, 2020-11-12)

  Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function ...
• Case Report: An unusual case of bee envenomation presenting with acute kidney injury, cavernous venous thrombosis and multiple episodes of convulsions 

  Walter Otieno, Macrine Olwala, George Michael Odhiambo Owiti (Peertechz, 2020-11-07)

  Bee stings are common in the tropics and cause minor problems but may occasionally cause severe anaphylactoid reactions. Summary of clinical case: We present a case of M.O.O., an 8-year-old boy who was stung three times ...
• Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya 

  Paul Kosiyo, Walter Otieno, Jesse Gitaka, Elly O Munde, Collins Ouma (BioMed Central, 2020-12)

  Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P. falciparum endemic regions such as western ...
• Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya 

  Helen M Nabwera, Dingmei Wang, Olukemi O Tongo, Pauline EA Andang’o, Isa Abdulkadir, Chinyere V Ezeaka, Beatrice N Ezenwa, Iretiola B Fajolu, Zainab O Imam, Martha K Mwangome, Dominic D Umoru, Abimbola E Akindolire, Walter Otieno, Grace M Nalwa, Alison W Talbert, Ismaela Abubakar, Nicholas D Embleton, Stephen J Allen, Neonatal Nutrition Network (NeoNuNet) (Public Library of Science, 2021-01-14)

  Objective To describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria. Study design In a network of seven secondary and tertiary level ...
• Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia 

  Harshil Gumasana, Walter Otieno (Peertechz, 2021-01-19)

  Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly and adequately treated. In 2018 WHO put the incidence of P. falciparum Malaria in the African region ...
• Clinical laboratory hematology reference values among infants aged 1month to 17 months in Kombewa Sub-County, Kisumu: A cross sectional study of rural population in Western Kenya 

  Jew Ochola Ouma, David H Mulama, Lucas Otieno, John Owuoth, Bernhards Ogutu, Janet Oyieko, Jackson C Korir, Peter Sifuna, Valentine Singoei, Victorine Owira, Stacey Maureen Okallo Gondii, Ben Andagalu, Walter Otieno (Public Library of Science, 2021-03-17)

  There is an urgent need for reliable region-specific hematological reference values for clinical monitoring. Laboratory reference ranges are important for assessing study participant eligibility, toxicity grading and ...

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