| dc.contributor.author | Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in Western Kenya who have uncomplicated malaria | |
| dc.date.accessioned | 2021-01-08T09:11:55Z | |
| dc.date.available | 2021-01-08T09:11:55Z | |
| dc.date.issued | 2008 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/3499 | |
| dc.description.abstract | Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by
the malaria parasite.We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to
assess the effect that folate supplementation has on SP failure in
467 pregnantwomenwere analyzed.Plasma folatelevelswere determined at enrollment and at day 7. High baseline folate levels,
high parasite densities, and age<20 yearswere risk factors for SP
failure. High-dose (5 mg daily) folate supplementation or high
folate levels at day 7 were independent risk factors. Therefore,
pregnant women receiving SP should receive low-/moderatedose folate supplementation | en_US |
| dc.publisher | The University of Chicago Press | en_US |
| dc.title | Anna M van Eijk, Peter O Ouma, John Williamson, Feiko O Ter Kuile, Monica Parise, Kephas Otieno, Mary J Hamel, John G Ayisi, Simon Kariuki, Piet A Kager, Laurence Slutsker | en_US |
| dc.type | Article | en_US |
