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Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial

Jacek Skarbinski, Peter O Ouma, Louise M Causer, Simon K Kariuki, John W Barnwell, Jane A Alaii, Alexandre Macedo de Oliveira, Dejan Zurovac, Bruce A Larson, Robert W Snow, Alexander K Rowe, Kayla F Laserson, Willis S Akhwale, Laurence Slutsker, Mary J Hamel (The American Society of Tropical Medicine and Hygiene, 2009)

Shortly after Kenya introduced artemether-lumefantrine (AL) for first-line treatment of uncomplicated malaria, we conducted a pre-post cluster randomized controlled trial to assess the effect of providing malaria rapid ...

Antifolate Resistance in Plasmodium falciparum: Multiple Origins and Identification of Novel dhfr Alleles

Andrea M McCollum, Amanda C Poe, Mary Hamel, Curtis Huber, Zhiyong Zhou, Ya Ping Shi, Peter Ouma, John Vulule, Peter Bloland, Laurence Slutsker, John W Barnwell, Venkatachalam Udhayakumar, Ananias A Escalante (The University of Chicago Press, 2006)

BackgroundSulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype ...

Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?

Mary J Hamel, Carolyn Greene, Tom Chiller, Peter Ouma, Christina Polyak, Kephas Otieno, John Williamson, Ya Ping Shi, Daniel R Feikin, Barbara Marston, John T Brooks, Amanda Poe, Zhiyong Zhou, Benjamin Ochieng, Eric Mintz, Laurence Slutsker (The American Society of Tropical Medicine and Hygiene, 2008)

We assessed the effect of daily cotrimoxazole, essential for HIV care, on development of antifolateresistant Plasmodium falciparum, naso-pharyngeal Streptococcus pneumoniae (pneumococcus), and commensal Escherichia coli. ...

Malaria and anaemia among pregnant women at first antenatal clinic visit in Kisumu, western Kenya

Peter Ouma, Anna M Van Eijk, Mary J Hamel, Monica Parise, John G Ayisi, Kephas Otieno, Piet A Kager, Laurence Slutsker (Blackwell Publishing Ltd, 2007)

objective To determine the prevalence of malaria and anaemia among urban and peri-urban women attending their first antenatal clinic (ANC) in an area of perennial malaria transmission. methods Between November 2003 and ...

The effect of health care worker training on the use of intermittent preventive treatment for malaria in pregnancy in rural western Kenya

PO Ouma, AM Van Eijk, MJ Hamel, E Sikuku, F Odhiambo, K Munguti, JG Ayisi, PA Kager, L Slutsker (Blackwell Publishing Ltd, 2007)

background In 1998, Kenya adopted intermittent preventive treatment (IPTp) with sulphadoxinepyrimethamine (SP) for malaria prevention during pregnancy. We conducted a survey in 2002 among women who had recently delivered ...

Performance of malaria rapid diagnostic tests as part of routine malaria case management in Kenya

Alexandre Macedo De Oliveira, Jacek Skarbinski, Peter O Ouma, Simon Kariuki, John W Barnwell, Kephas Otieno, Phillip Onyona, Louise M Causer, Kayla F Laserson, Willis S Akhwale, Laurence Slutsker, Mary Hamel (The American Society of Tropical Medicine and Hygiene, 2009)

Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited. We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria case ...

A randomized controlled trial of folate supplementation when treating malaria in pregnancy with sulfadoxine-pyrimethamine

Peter Ouma, Monica E Parise, Mary J Hamel, Feiko O Ter Kuile, Kephas Otieno, John G Ayisi, Piet A Kager, Richard W Steketee, Laurence Slutsker, Anna M Van Eijk (Public Library of Science, 2006)

Objectives: Sulfadoxine-pyrimethamine (SP) is an antimalarial drug that acts on the folate metabolism of the malaria parasite. We investigated whether folate (FA) supplementation in a high or a low dose affects the ...

Anna M van Eijk, Peter O Ouma, John Williamson, Feiko O Ter Kuile, Monica Parise, Kephas Otieno, Mary J Hamel, John G Ayisi, Simon Kariuki, Piet A Kager, Laurence Slutsker

Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in Western Kenya who have uncomplicated malaria (The University of Chicago Press, 2008)

Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite.We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate ...