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Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?

Mary J Hamel, Carolyn Greene, Tom Chiller, Peter Ouma, Christina Polyak, Kephas Otieno, John Williamson, Ya Ping Shi, Daniel R Feikin, Barbara Marston, John T Brooks, Amanda Poe, Zhiyong Zhou, Benjamin Ochieng, Eric Mintz, Laurence Slutsker (The American Society of Tropical Medicine and Hygiene, 2008)

We assessed the effect of daily cotrimoxazole, essential for HIV care, on development of antifolateresistant Plasmodium falciparum, naso-pharyngeal Streptococcus pneumoniae (pneumococcus), and commensal Escherichia coli. ...

Anna M van Eijk, Peter O Ouma, John Williamson, Feiko O Ter Kuile, Monica Parise, Kephas Otieno, Mary J Hamel, John G Ayisi, Simon Kariuki, Piet A Kager, Laurence Slutsker

Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in Western Kenya who have uncomplicated malaria (The University of Chicago Press, 2008)

Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite.We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate ...