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Antifolate Resistance in Plasmodium falciparum: Multiple Origins and Identification of Novel dhfr Alleles
(The University of Chicago Press, 2006)
BackgroundSulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype ...
A randomized controlled trial of folate supplementation when treating malaria in pregnancy with sulfadoxine-pyrimethamine
(Public Library of Science, 2006)
Objectives: Sulfadoxine-pyrimethamine (SP) is an antimalarial drug that acts on the folate
metabolism of the malaria parasite. We investigated whether folate (FA) supplementation in a
high or a low dose affects the ...