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Antifolate Resistance in Plasmodium falciparum: Multiple Origins and Identification of Novel dhfr Alleles

Andrea M McCollum, Amanda C Poe, Mary Hamel, Curtis Huber, Zhiyong Zhou, Ya Ping Shi, Peter Ouma, John Vulule, Peter Bloland, Laurence Slutsker, John W Barnwell, Venkatachalam Udhayakumar, Ananias A Escalante (The University of Chicago Press, 2006)

BackgroundSulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype ...

A randomized controlled trial of folate supplementation when treating malaria in pregnancy with sulfadoxine-pyrimethamine

Peter Ouma, Monica E Parise, Mary J Hamel, Feiko O Ter Kuile, Kephas Otieno, John G Ayisi, Piet A Kager, Richard W Steketee, Laurence Slutsker, Anna M Van Eijk (Public Library of Science, 2006)

Objectives: Sulfadoxine-pyrimethamine (SP) is an antimalarial drug that acts on the folate metabolism of the malaria parasite. We investigated whether folate (FA) supplementation in a high or a low dose affects the ...