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Antifolate Resistance in Plasmodium falciparum: Multiple Origins and Identification of Novel dhfr Alleles

Andrea M McCollum, Amanda C Poe, Mary Hamel, Curtis Huber, Zhiyong Zhou, Ya Ping Shi, Peter Ouma, John Vulule, Peter Bloland, Laurence Slutsker, John W Barnwell, Venkatachalam Udhayakumar, Ananias A Escalante (The University of Chicago Press, 2006)

BackgroundSulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype ...