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Sigmoid volvulus in pregnancy
(Annals of African Surgery., 2019)
Sigmoid volvulus in pregnancy is a rare condition that poses a myriad of challenges in diagnosis and management of the patient. It demands on the clinician a high index of suspicion, immediate treatment involving resuscitation ...
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in …
(Elsevier, 2019-07-01)
Background: Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium
falciparum regions.
Methods: To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome ...
Quality Blood Sampling Techniques and Influence of Socio cultural Factors among ARVs Forces Community in Seeking Healthcare
(SMU Medical Journal, 2016-01)
Project monitoring and evaluation (M/E) determines resource accountability and its impact to
various stakeholders. Plenary project success requires holistic community participation and
empowerment. However, this approach ...
Evaluation of the Parasight platform for malaria diagnosis
(American Society for Microbiology Journals, 2017-03-01)
The World Health Organization estimates that nearly 500 million malaria tests are performed annually. While microscopy and rapid diagnostic tests (RDTs) are the main diagnostic approaches, no single method is inexpensive, ...
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide
(Nature Publishing Group, 2019-04-17)
Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ...
Duffy Antigen/Receptor for Chemokines (DARC): Is There a Role in Prostate Cancer?.
(American Society of Hematology, 2005-11-16)
Introduction: The Duffy blood group antigens function as chemokine receptors and as receptors for several species of malarial parasites. Approximately 70% of African Americans are Duffy negative as a result of a single ...
Reduced interferon (IFN)-α conditioned by IFNA2 (− 173) and IFNA8 (− 884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all
(Springer-Verlag, 2012-08-01)
Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ...
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(BioMed Central, 2013-12-01)
In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA,
hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
Expression profiling of Trypanosoma congolense genes during development in the tsetse fly vector Glossina morsitans morsitans
(BioMed Central, 2018-12)
The tsetse transmitted parasitic flagellate Trypanosoma congolense causes animal African trypanosomosis (AAT) across sub-Saharan Africa. AAT negatively impacts agricultural, economic, nutritional and subsequently, health ...
The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis
(Springer, New York, NY, 2013)
Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ...