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Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?
(The American Society of Tropical Medicine and Hygiene, 2008)
We assessed the effect of daily cotrimoxazole, essential for HIV care, on development of antifolateresistant Plasmodium falciparum, naso-pharyngeal Streptococcus pneumoniae (pneumococcus), and commensal Escherichia coli. ...
Malaria and anaemia among pregnant women at first antenatal clinic visit in Kisumu, western Kenya
(Blackwell Publishing Ltd, 2007)
objective To determine the prevalence of malaria and anaemia among urban and peri-urban women
attending their first antenatal clinic (ANC) in an area of perennial malaria transmission.
methods Between November 2003 and ...
The effect of health care worker training on the use of intermittent preventive treatment for malaria in pregnancy in rural western Kenya
(Blackwell Publishing Ltd, 2007)
background In 1998, Kenya adopted intermittent preventive treatment (IPTp) with sulphadoxinepyrimethamine (SP) for malaria prevention during pregnancy. We conducted a survey in 2002 among
women who had recently delivered ...
Performance of malaria rapid diagnostic tests as part of routine malaria case management in Kenya
(The American Society of Tropical Medicine and Hygiene, 2009)
Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited.
We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria
case ...
Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L …
(Royal Society of Tropical Medicine and Hygiene, 2008)
Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured ...
A randomized controlled trial of folate supplementation when treating malaria in pregnancy with sulfadoxine-pyrimethamine
(Public Library of Science, 2006)
Objectives: Sulfadoxine-pyrimethamine (SP) is an antimalarial drug that acts on the folate
metabolism of the malaria parasite. We investigated whether folate (FA) supplementation in a
high or a low dose affects the ...
Anna M van Eijk, Peter O Ouma, John Williamson, Feiko O Ter Kuile, Monica Parise, Kephas Otieno, Mary J Hamel, John G Ayisi, Simon Kariuki, Piet A Kager, Laurence Slutsker
(The University of Chicago Press, 2008)
Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by
the malaria parasite.We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to
assess the effect that folate ...
Immediate postoperative pain management in adult patients following orthopaedic surgery at the Kenyatta national hospital
(University of Nairobi, 2007)
Background: Postoperative pain is a major challenge in the care of surgical patients yet pain therapy is a central medical task and a legal duty and optimum pain control is a fundamental right for all patients. Objective: ...
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
(Pub Med Central, 2009-11-17)
OBJECTIVE:
RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis ...
Pitting of malaria parasites and spherocyte formation
(Pub Med Central, 2006-07-31)
BACKGROUND:
A high prevalence of spherocytes was detected in blood smears of children enrolled in a case control study conducted in the malaria holoendemic Lake Victoria basin. It was speculated that the spherocytes ...