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Now showing items 11-18 of 18
Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?
(The American Society of Tropical Medicine and Hygiene, 2008)
We assessed the effect of daily cotrimoxazole, essential for HIV care, on development of antifolateresistant Plasmodium falciparum, naso-pharyngeal Streptococcus pneumoniae (pneumococcus), and commensal Escherichia coli. ...
Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L …
(Royal Society of Tropical Medicine and Hygiene, 2008)
Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured ...
Anna M van Eijk, Peter O Ouma, John Williamson, Feiko O Ter Kuile, Monica Parise, Kephas Otieno, Mary J Hamel, John G Ayisi, Simon Kariuki, Piet A Kager, Laurence Slutsker
(The University of Chicago Press, 2008)
Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by
the malaria parasite.We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to
assess the effect that folate ...
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia
(The Feinstein Institute for Medical Research, 2008-03)
Plasmodium falciparum malaria causes 1–2 million deaths per year. Most deaths
occur as a result of complications such as severe anemia and cerebral malaria (CM)(coma).
Red cells of children with severe malaria-associated ...
Medicinal plants used in the treatment of fungal and bacterial infections in and around Queen Elizabeth Biosphere Reserve, western Uganda
(Blackwell Publishing Ltd, 2008-06-01)
In Uganda, bacterial and fungal infections are prevalent especially, the sexually
transmitted diseases including HIV/AIDS. Because of low socio-economic empowerment,
traditional beliefs and cultural barriers, the ...
Risk of conjunctival contamination from blood splashes during surgery at the Kenyatta National Hospital, Nairobi
(East African medical journal, 2008-12-15)
Objectives: To determine the utilisation rate of design specific eye protection by surgeons and to assess the risk of conjunctival contamination with blood splashes during surgery.
Design: Cross sectional, observational ...
Rachs-1 system in rist stratification for congenital heart disease surgery outcome
(East African medical journal, 2008-05-28)
Background: The Risk Adjustment in Congenital Heart Surgery (RACHS-1) system has been used as a benchmark to compare surgical results in developed countries. Its ability to stratify postoperative mortality risk has been ...
Ortner syndrome
(South African Journal of Child Health, 2008)
Ortner syndrome, or cardio-vocal syndrome, is a clinical entity characterised by hoarseness (secondary to left-sided recurrent laryngeal nerve palsy) caused by cardiovascular disease. It has been reported in up to 12% of ...