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Clinical and molecular evidence for a case of Buruli ulcer (Mycobacterium ulcerans infection) in Kenya
(The American Society of Tropical Medicine and Hygiene, 2009)
Mycobacterium ulcerans infection is an emerging disease that causes indolent, necrotizing skin lesions known
as Buruli ulcer (BU) and occasional contiguous or metastatic bone lesions. Buruli ulcer is named after Buruli ...
COMPLEMENT REGULATORY PROTEIN LEVELS IN CHILDREN WITH SICKLE CELL TRAIT
(Nairobi university, 2009)
Sickle cell disease refers to a collection of autosomal recessive genetic disorders characterized by the presence of HbS variant of the globin chain while “sickle cell anaemia” refers to individuals with two copies of the ...
Validity/reliability of PHQ-9 and PHQ-2 depression scales among adults living with HIV/AIDS in western Kenya
(Springer-Verlag, 2009-02-01)
Background
Depression greatly burdens sub-Saharan Africa, especially populations living with HIV/AIDS, for whom few validated depression scales exist. Patient Health Questionnaire-9 (PHQ-9), a brief dual-purpose instrument ...
Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial
(The American Society of Tropical Medicine and Hygiene, 2009)
Shortly after Kenya introduced artemether-lumefantrine (AL) for first-line treatment of uncomplicated
malaria, we conducted a pre-post cluster randomized controlled trial to assess the effect of providing malaria rapid ...
Performance of malaria rapid diagnostic tests as part of routine malaria case management in Kenya
(The American Society of Tropical Medicine and Hygiene, 2009)
Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited.
We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria
case ...
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
(Pub Med Central, 2009-11-17)
OBJECTIVE:
RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis ...
Functional characterization and protein–protein interactions of trypanosome splicing factors U2AF35, U2AF65 and SF1
(Elsevier, 2009-04-01)
Early in the assembly of the spliceosome of eukaryotes the branch-point binding protein (BBP, also called SF1) recognizes the branch point sequence, whereas the heterodimer U2AF consisting of a 65 and a 35 kDa subunit, ...
The role of echocardiography in diagnosing carditis in the setting of acute rheumatic fever
(Cambridge University Press, 2009-08)
Sir,
Vijayalakshmi and her colleagues are to be
commended for their paper.1 We disagree, however,
with the use of a scoring system to make an
echocardiographic diagnosis of carditis due to acute
rheumatic fever. We ...
The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
(BioMed Central, 2009-12-01)
Background
The mitochondrial DNA (mtDNA) T16189C polymorphism, with a homopolymeric C-tract of 10–12 cytosines, is a putative genetic risk factor for idiopathic dilated cardiomyopathy in the African and British populations. ...
A global" School for Surgeons" could help bridge the Healthcare Human Resource Crisis in Sub-Saharan Africa
(University of Nairobi, 2009)
Appropriately designed elearning programmes (including Best or School for Surgeons) may allow more efficient use of consultant teaching time. Using funding from Irish Aid, we piloted these existing e-learning tools in a ...