Browsing School of Medicine by Title
Now showing items 409-428 of 553
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Plasmodium falciparum Infection Modulates Platelet Count than Leucocyte Parameters in Carriage of Different Haemoglobin Beta Subunit (HBB) Genotypes
(International Knowledge sharing platform, 2023)Sickle cell disease is a prime genetic disorder due to a single nucleotide mutation resulting in haemoglobin gene (HbS) occurring in the regions where malaria is endemic. Though it primarily a disease of erythrocytes, ... -
Point mutation (C446S) in the thyroid hormone receptor β gene in a black South African kindred with thyroid hormone resistance syndrome
(1999)Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS/Unless otherwise stated above, the content of this bibliographic record may ... -
Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria
(Pub Med Central, 2011-08)BACKGROUND: Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young ... -
Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating Gamma Interferon Levels
(American Society for Microbiology, 2012)An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) ... -
Population-specific evolution of HIV Gag epitopes in genetically diverged patients
(Elsevier, 2013-06-01)Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures ... -
Post Oesophagectomy Leakage at Kenyatta National Hospital–Nairobi-Kenya
(East and Central African Journal of Surgery, 2005)Background: Post oesophagectomy leakage is a common postoperative complication. This present review was aimed at documenting the problem of post-oesophagectomy leakage and associated variables at Kenyatta National Hospital ... -
Post-infarction ventricular septal defect in Nairobi: Case report
(Kenya Medical Association, 2015-12)Post infarction ventricular septal defect results from perforation of the ventricular septum secondary to ischaemic injury following myocardial infarction. Ischaemic heart disease till recently was thought to be an uncommon ... -
The Potential of Differentiation-Related Gene-1 (DRG1) as a Biomarker for Metastasis of Estrogen Receptor-Positive Breast Cancer
(Journal of Advances in Medicine and Medical Research(JAMMR), 2021)Breast cancer is major burden worldwide and the majority of breast cancers express estrogen receptors (ER) suggesting a high dependence on estrogen hormone. Age is among the major determinants of breast cancer development, ... -
Prediction of BRCA Mutations Using the BRCAPRO Model in Clinic-Based African American, Hispanic, and Other Minority Families in the United States
(American Society of Clinical Oncology, 2009)BRCAPRO, a BRCA mutation carrier prediction model, was developed on the basis of studies in individuals of Ashkenazi Jewish and European ancestry. We evaluated the performance of the BRCAPRO model among clinic-based minority ... -
Predictors of Advocating Safe Health Population when Handling Sars-Cov-2 Morbidities and Mortality to Enable Safe Disposal and Mediate Efficient Community Live Hoods
(2021)Predictors to mediate Safe Health Population during active SARS-CoV-2, (COVID, 19), a Public Health, not Curative Challenge as perceived by majority globally and regionally are predetermined by comprehensive and holistic ... -
Predictors of Ocular Surface Squamous Neoplasia and Conjunctival Squamous Cell Carcinoma among Ugandan Patients: A Hospital-based Study
(Wolters Kluwer--Medknow Publications, 2018)AIM: The aim of the study was to assess the predictors of ocular surface squamous neoplasia (OSSN) and conjunctival squamous cell carcinoma (SCC) among Ugandan patients. MATERIALS AND METHODS: Patients presenting for ... -
Pregnancy in open heart surgical patients at Kenyatta National Hospital.
(East African medical journal, 1999-01-01)In the past, the Kenyatta National Hospital heart unit policy has been to discourage pregnancy among patients following open heart surgery for valve replacement, in view of the adverse effects of warfarin. OBJECTIVE: To ... -
The pregnancy outcomes of female albino rats (Rattus Norvegicus) exposed prenatally to varied doses of lamotrigine
(AJOL, 2023-03-03)The maternal pregnancy outcomes following the in-utero exposure to lamotrigine (LAMT), a second-generation anticonvulsant medicine, have not been well elucidated. Lamotrigine is currently being prescribed widely and ... -
Prevalence and Factors Associated with Depression among Patients with Epilepsy at Aga Khan University Teaching Hospital Nairobi
(2015-10-01)Objective: To determine the prevalence and factors associated with depression in patients with epilepsy at Aga Khan University Hospital; Nairobi. Design: A Cross-Sectional Survey. Setting: Neurology clinic, Aga Khan ... -
Prevalence and incidence of congenital anomalies amongst babies born to women with sickle cell disease and exposed to hydroxyurea during pregnancy: a systematic review protocol
(2018)What is the prevalence and incidence of congenital anomalies among babies born to women with sickle cell disease (SCD) and who have been exposed to hydroxyurea (HU) therapy at any time in their pregnancy? The objective ... -
Prevalence of khat chewers among primary health clinic attenders in Kenya
(Blackwell Publishing Ltd, 1987-03)In a rural district hospital in Kenya, the authors screened 100 randomly selected outpatients for khat (miraa) chewing. A surprisingly high number of them admitted chewing khat leaves. The implications of this finding and ... -
Prevalence of metabolic syndrome components among University students in Kenya
(East African Medical Journal, 2018)Objective: To examine the prevalence and major components of MS among Maseno University students. Design: Descriptive cross- sectional study design Setting: Maseno University, Medical Physiology laboratory Participants: ... -
Prevalence of transmitted drug resistance mutations in HIV-1-infected drug-naive patients from urban and suburban regions of Kenya
(Mary Ann Liebert, Inc., 2016-03-01)HIV was first described in Kenya in 1984–1985. Currently, Kenya has an estimated HIV-1 prevalence of 6.2%. With the introduction of antiretroviral drugs, the survival of most HIV patients has been prolonged markedly. ... -
Prevalence of transmitted drug resistance mutations in HIV-1-infected drug-naive patients from urban and suburban regions of Kenya
(Mary Ann Liebert, Inc., 2016-03-01)Abstract HIV was first described in Kenya in 1984–1985. Currently, Kenya has an estimated HIV-1 prevalence of 6.2%. With the introduction of antiretroviral drugs, the survival of most HIV patients has been prolonged ... -
Prevalence, Associated Risk Factors and Progression Of Asymptomatic Peripheral Arterial Disease At Kenyatta National Hospital
(University of Nairobi, 2016)The prevalence of peripheral arterial disease worldwide has been estimated at between 4.5% and 29%. Peripheral arterial disease can be asymptomatic or symptomatic. It is an independent risk factor for cardiovascular morbidity ...